Intra-arterial delivery of the mesenchymal stem cells to ischemic rat brain
Kim, Geuhee; Shin, Dong Hoon; Lee, Young-Don; Hong, Jiman; Kim, Sung-Soo; Suh-Kim, Haeyoung
Department of Anatomy, Ajou University School of Medicine; Center for Cell Death Regulating Biodrug, Ajou Research Institute for Innovative Medicine; Department of Neurology, Ajou University School of Medicine
Mesenchymal stem cells (MSCs) have been shown to improve a variety of neurological dysfunction by their paracrine effects. Previously, we showed that most therapeutic fucntions of MSCs are dependent on their paracrine functions in a rat stroke model. We also showed that intracranial transplantation of neuronally induced MSCs with Neurogenin-1 (Ngn1), a developmental regulator of the nervous system, markedly improved motor functions through transdifferentiating into neurons. However, intracranial injection of stem cells to the iscemic brain is invasive, and, thus, unable to be applicable to some stroke patients. In this study, we established a less invasive method to deliver MSCs through the internal carotid artery and evaluated whether therapeutic outcome is comparable to that of intracranial transplantation. We will further discuss the effects of intra-arterial delivery of stem cells compared to the intracranial transplantation.
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