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Comparison of diffusion-weighted mri and mr volumetry in the evaluation of early treatment outcomes after preoperative chemoradiotherapy for locally advanced rectal cancer.

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dc.contributor.authorKim, YC-
dc.contributor.authorLim, JS-
dc.contributor.authorKeum, KC-
dc.contributor.authorKim, KA-
dc.contributor.authorMyoung, S-
dc.contributor.authorShin, SJ-
dc.contributor.authorKim, MJ-
dc.contributor.authorKim, NK-
dc.contributor.authorSuh, J-
dc.contributor.authorKim, KW-
dc.date.accessioned2012-05-02T04:58:08Z-
dc.date.available2012-05-02T04:58:08Z-
dc.date.issued2011-
dc.identifier.issn1053-1807-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6680-
dc.description.abstractPURPOSE: To compare diffusion-weighted imaging (DWI) and magnetic resonance (MR) volumetry for predicting treatment outcomes of locally advanced rectal cancers with preoperative chemoradiotherapy (CRT).



MATERIALS AND METHODS: This prospective study was approved by our Institutional Review Board. Thirty-four patients underwent three MR examinations: pre-CRT (before CRT), early CRT (2 weeks after CRT initiation), and post-CRT (before surgery). The tumor apparent diffusion coefficient (ADC), ADC increase rate, and volume reduction rate were compared between responders and nonresponders using three reference standards: downstaging, modified Response Evaluation Criteria in Solid Tumors (mRECIST), and tumor regression grade (TRG). For DWI and volumetry, differences between responders and nonresponders were assessed by receiver operating characteristic analysis.



RESULTS: The median early tumor volume reduction rate of responders, subgrouped by downstaging and mRECIST (47.97% and 53.97%, respectively), was significantly higher than that of nonresponders (20.94% and 20.36%; P = 0.0024 and 0.0001, respectively), but there were no significant differences in pre-CRT ADC and early ADC increase rate using all references. When using the downstaging and mRECIST, the diagnostic performance of early tumor volume reduction rate (Az = 0.81 and 0.94, respectively) was higher than that of pre-CRT ADC (Az = 0.55 and 0.62; P = 0.033 and 0.007) and early ADC increase rate (Az = 0.58 and 0.64; P = 0.055 and 0.01) for predicting the treatment outcome. For TRG, there were no significant differences between DWI and volumetry.



CONCLUSION: Early tumor volume reduction rate at the second week after CRT initiation may be a better indicator than DWI based on the mean ADC measurements for predicting CRT treatment outcome.
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dc.language.isoen-
dc.titleComparison of diffusion-weighted mri and mr volumetry in the evaluation of early treatment outcomes after preoperative chemoradiotherapy for locally advanced rectal cancer.-
dc.typeArticle-
dc.identifier.pmid21751285-
dc.contributor.affiliatedAuthor김, 영철-
dc.type.localJournal Papers-
dc.identifier.doi10.1002/jmri.22696-
dc.citation.titleJournal of magnetic resonance imaging : JMRI-
dc.citation.volume34-
dc.citation.number3-
dc.citation.date2011-
dc.citation.startPage570-
dc.citation.endPage576-
dc.identifier.bibliographicCitationJournal of magnetic resonance imaging : JMRI, 34(3). : 570-576, 2011-
dc.identifier.eissn1522-2586-
dc.relation.journalidJ010531807-
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Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
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