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Comparison of behavior of inflammatory cells in response to injury in PINK1 deficient mice with wild-type mice

Byun, Jiwon; Kim, Jun; Jeong, Hey-kyeong; Joe, Eunhye
Department of Pharmacology, Ajou University School of Medicine
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. It is caused by progressive dopaminergic neuronal loss in the substantia nigra, characterized by rigidity, tremors and slowness of movement. PINK1 is a well-known PD related gene, but PINK1 knock-out mice did not show any sign of PD symptom. Since PINK1 is expressed in microglia/monocytes and astrocytes that play important roles in inflammation in injured brain, we examined whether PINK1 could alter the behavior of microglia/monocytes and astrocytes in injured brain. Thus, we injected ATP into the SNpc of young adult (8-week-old), and middle-aged (10-month-old) WT and KO mice, and compared the behavior of these cells, and wound healing capability. WT and KO mice showed similar extent of damage in response to ATP injection. Furthermore, WT and KO mice did not show significant difference in either behavior of microglia/monocytes and astrocytes or wound healing capability. Therefore, PINK1 may not be related to behavior of microglia/monocytes and astrocytes and healing capability at least at these ages.
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