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Urinary GADD45gamma expression is associated with progression of lgA nephropathy.

Authors
Yu, S; Cho, J; Park, I; Kim, SJ; Kim, H; Shin, GT
Citation
American journal of nephrology, 30(2):135-139, 2009
Journal Title
American journal of nephrology
ISSN
0250-80951421-9670
Abstract
BACKGROUND: Growth arrest and DNA damage-45gamma (GADD-45gamma) is induced in response to environmental stresses and functions in the regulation of cell cycles. Previous findings by our group suggested that GADD45gamma contributed to renal tubular cell damage through induction of inflammatory and fibrogenic molecules. We examined the effects of urinary GADD45gamma expression on the decline in renal function with IgA nephropathy in the present study. METHODS: Patients (n = 62) were followed for a total of 710.3 +/- 287.5 days. The rate of renal function decline was assessed by the slopes of inverse serum creatinine and estimated glomerular filtration rate (GFR) plotted against time. Renal survival was calculated by Kaplan-Meier analysis and the primary endpoint was an increase in serum creatinine levels by 50% or more. RESULTS: Kidney function declined more rapidly in the GADD45gamma-positive group compared to the GADD45gamma-negative group. Kidney survival estimates at the end of the study period were 82.9% in the GADD45gamma-positive group and 100% in the negative group (p = 0.03). This difference remained significant in the group with GFR values <90 ml/min/1.73 m2 when adjusted to stratification factors. CONCLUSION: The results suggest that urinary GADD45gamma expression is associated with progression of renal disease.
MeSH terms
AdultCreatinine/bloodDisease ProgressionFemaleGene Expression Regulation*Glomerular Filtration RateGlomerulonephritis, IGA/diagnosisGlomerulonephritis, IGA/urine*HumansIntracellular Signaling Peptides and Proteins/urine*Kidney/pathology*`Kidney Function TestsMaleMiddle AgedPolymerase Chain ReactionTime Factors
DOI
10.1159/000209317
PMID
19293565
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nephrology
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