The roles of spartin in Drosophila circadian clock
Lee, Euna; Jeong, Eun Hee; Lee, Min Jung; Nahm, Minyeop; Lee, Seungbok; Kim, Eun Young
Graduate School of Biomedical Sciences
Hereditary spastic paraplegias(HSPs) are a group of neurological disorders characterized by muscle weakness and progressive spasticity in lower limb.
Troyer syndrome is an autosomal recessive form of HSPs caused by a frameshift mutation in the spartin(SPG20) gene encoding SPARTIN protein.
We developed Drosophila Troyer syndrome model in which spartin gene is deleted via P-element mutagenesis, named spartin1. To examine motor behavior of spartin1 flies, we measured locomotion of spartin1 flies. Unexpectedly, spartin1 flies manifested rhythmicity with longer period, 27hr suggesting that SPARTIN might play a role in circadian clock system.
Furthermore, ectopic expression of spartin in neurons rescued the circadian phenotype of spartin1 flies indicating that alterations in circadian behavior were caused by spartin loss of function.
Thus, we sought to examine the role of spartin in circadian clock system.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,770,954
Total Download :1,130,675
Today View :614
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.