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The roles of spartin in Drosophila circadian clock

Authors
Lee, Euna; Jeong, Eun Hee; Lee, Min Jung; Nahm, Minyeop; Lee, Seungbok; Kim, Eun Young
Department
Graduate School of Biomedical Sciences
Abstract
Hereditary spastic paraplegias(HSPs) are a group of neurological disorders characterized by muscle weakness and progressive spasticity in lower limb.

Troyer syndrome is an autosomal recessive form of HSPs caused by a frameshift mutation in the spartin(SPG20) gene encoding SPARTIN protein.

We developed Drosophila Troyer syndrome model in which spartin gene is deleted via P-element mutagenesis, named spartin1. To examine motor behavior of spartin1 flies, we measured locomotion of spartin1 flies. Unexpectedly, spartin1 flies manifested rhythmicity with longer period, 27hr suggesting that SPARTIN might play a role in circadian clock system.

Furthermore, ectopic expression of spartin in neurons rescued the circadian phenotype of spartin1 flies indicating that alterations in circadian behavior were caused by spartin loss of function.

Thus, we sought to examine the role of spartin in circadian clock system.
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