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Hepatitis B Virus Replication Alter Microtubule Dynamics

Kim, Hye-Young; Jung, Jaesung; Kim, Kyongmin
Department of Microbiology, Ajou University School of Medicine
Since hepatitis B virus covalently closed circular DNA was detected in HBV replicating stable cells that contain HBV wt, but not in HBV non-replicating priming deficient mutant containing stable cells, cellular transport system must discriminate among mature replicative-intermediate DNA- and immature RNA-containing core particles to recycle DNA-containing core particles back to nucleus. HBV wt core particles consist of both mature and immature core particles, priming-deficient mutant core particles consist of only the immature core particles. Since intranuclear core particles were decreased by nocodazole and taxol in HBV replicating stable cells but not in non-replicating cells, microtubule dynamics might be affected by HBV replications. Acetylated tubulin was also decreased in HBV replicating stable cells. Taken together these results suggest that HBV replication alter the microtubule dynamics to transport mature core particles toward nucleus.
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