Vulnerability of Neonatal Seizure with Little COX Activity
Chung, Jee-In; Baik, Eun Joo
Department of Physiology, Ajou University School of Medicine; Chronic Inflammatory Disease Research Center, Ajou Research Institute for Innovative Medicine
Epilepsia is a disorder characterized by recurrent seizures, is the second most common neurological disorder. Even though seizures can occur at any age, but they are more common in children than adults. Most neonatal seizures are extremely difficult to control with currently available anti epileptic drugs (AEDs). In previous our reports, COX-2 inhibitors aggravate kainic acid (KA)-induced seizures and prostaglandin F2 alpha (PGF2α) act as endogenous anticonvulsant through FP receptor in the adult mice. Therefore, we assumed whether PGF2α act as an anticonvulsant on KA-induced neonatal seizure. In this study, post-natal day 9 mice are far more prone to seizures than the adult. The seizure activities in the adult showed less than those in the neonate, which was aggravated by COX inhibition. However, the neonate seizure levels were not affected by COX inhibition. Interestingly, COX expression of the brain during development increased. By western blot analysis and EIA assay, the immature neonate brain rarely expressed COX-2 and PGF2α with/without KA stimulation. Next, we administrated PGF2α intracisternally and pre-treatment of PGF2α reduced seizure activity in P9 mice. Taken together, little COX-2 and PGF2α may be suggested as one cause of neonatal vulnerability to seizure.
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