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Expression of excision repair cross-complementation group 1 protein predicts poor outcome in advanced non-small cell lung cancer patients treated with platinum-based doublet chemotherapy.

Lee, HW; Choi, YW; Han, JH; Kim, JH; Jung, JH; Jeong, SH; Kang, SY; Choi, JH; Oh, YT; Park, KJ; Hwang, SC; Sheen, SS
Lung cancer (Amsterdam, Netherlands), 65(3):377-382, 2009
Journal Title
Lung cancer (Amsterdam, Netherlands)
PATIENTS AND METHODS: Pretreatment tumor biopsy specimens from 50 patients with NSCLC including stage IIIB with malignant pleural effusion or stage IV or recurrent disease were analyzed for p53, Bcl-2, Bax, and ERCC1 expression by immunohistochemistry. All patients were treated with platinum-based third-generation doublet chemotherapy, in which gemcitabine and cisplatin was the most commonly administered regimen (17 patients).

RESULTS: High expression of p53, Bcl-2, Bax, and ERCC1 was observed in 24 (48%), 8 (16%), 32 (63%), and 28 (55%) patients, respectively. In univariate analysis, high expression of ERCC1 demonstrated a trend of association with poor overall survival (OS) (median, 8 months vs. 11 months; P=0.055). High expression of p53, Bcl-2, Bax was not correlated with patient outcome. High expression of ERCC1 was an independent prognostic factor for poor OS (P=0.002) along with poor performance status (P=0.028) and lack of disease control (P=0.001) in multivariate analysis.

CONCLUSIONS: High expression of ERCC1 may be a useful prognostic factor for poor outcome in advanced NSCLC patients treated with platinum and third-generation doublet chemotherapy.
MeSH terms
AdultAgedAntineoplastic Combined Chemotherapy Protocols/therapeutic use*Carcinoma, Non-Small-Cell Lung/diagnosisCarcinoma, Non-Small-Cell Lung/drug therapy*Carcinoma, Non-Small-Cell Lung/mortalityCarcinoma, Non-Small-Cell Lung/pathologyCarcinoma, Non-Small-Cell Lung/physiopathologyCisplatin/administration & dosageDNA-Binding Proteins/geneticsDNA-Binding Proteins/metabolism*Deoxycytidine/administration & dosageDeoxycytidine/analogs & derivativesDisease ProgressionDrug Resistance, NeoplasmEndonucleases/geneticsEndonucleases/metabolism*FemaleHumansImmunohistochemistryLung Neoplasms/diagnosisLung Neoplasms/drug therapy*Lung Neoplasms/mortalityLung Neoplasms/pathologyLung Neoplasms/physiopathologyMaleMiddle AgedNeoplasm StagingPlatinum/administration & dosagePleural Effusion, Malignant/diagnosisPleural Effusion, Malignant/drug therapy*Pleural Effusion, Malignant/mortalityPleural Effusion, Malignant/pathologyPleural Effusion, Malignant/physiopathologyPrognosisProto-Oncogene Proteins c-bcl-2/geneticsProto-Oncogene Proteins c-bcl-2/metabolismRecurrenceSurvival AnalysisTreatment OutcomeTumor Suppressor Protein p53/geneticsTumor Suppressor Protein p53/metabolismbcl-2-Associated X Protein/geneticsbcl-2-Associated X Protein/metabolism
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Plastic & Reconstructive Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
이, 현우한, 재호김, 장희정, 재호정, 성현강, 석윤최, 진혁오, 영택박, 광주황, 성철신, 승수
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