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Hemodynamic impact of fetal-variant Willisian circle on cerebral circulation: a duplex ultrasonography study.

Authors
Hong, JM; Lee, JS; Shin, DH; Yong, SW
Citation
European neurology, 65(6):340-345, 2011
Journal Title
European neurology
ISSN
0014-30221421-9913
Abstract
BACKGROUND/AIMS: The Willisian circle can redistribute the vertebrobasilar flow and the reduction of flow is attributable to orthrostatic presyncope. To evaluate this hemodynamic aspect, we investigated anterior and posterior cerebral blood flow (CBF) volume distributions according to the variation of the Willisian circle, and compared those between controls and patients with presyncope.



METHODS: Subjects underwent cerebral CT angiography and color-coded duplex sonography measuring flow volumes of the internal carotid artery (ICAs) and vertebral artery (VAs). According to clinical manifestations and Willisian configurations, CBF volume patterns were analyzed.



RESULTS: Between the presyncope (n = 25) and control groups (n = 76), the prevalence of fetal-variant Willisian configuration (48% vs. 21%, p = 0.004) and posterior CBF volume (126 ± 85 vs. 165 ± 64 ml/min, p = 0.015) was significantly different, but A1 morphology, anterior CBF, and total CBF volumes were not. Total CBF volume was 769 ± 176 ml/min (80% ICAs and 20% VAs). The posterior CBF volume lowered significantly (172 ± 70 vs. 122 ± 62 vs. 92 ± 44 ml/min; p < 0.001) toward the two-sided fetal type variation, although total CBF volume is similar among the three groups (p = 0.742).



CONCLUSIONS: The present study suggests that Willisian configuration contributes to orthostatic presyncope and flow distribution of the cerebral circulation.
MeSH terms
AgedAged, 80 and overCerebrovascular Circulation/*physiologyCircle of Willis/*ultrasonographyFemale*HemodynamicsHumansMaleMiddle AgedRetrospective Studies*Ultrasonography, Doppler, Transcranial
DOI
10.1159/000327213
PMID
21597296
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
홍, 지만이, 진수신, 동훈용, 석우
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