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Different associations of periventricular and deep white matter lesions with cognition, neuropsychiatric symptoms, and daily activities in dementia.

Authors
Park, KH; Lee, JY; Na, DL; Kim, SY; Cheong, HK; Moon, SY; Shim, YS; Park, KW; Ku, BD; Choi, SH; Joo, H; Lee, JS; Go, SM; Kim, SH; Kim, S; Cha, KR; Lee, J; Seo, SW
Citation
Journal of geriatric psychiatry and neurology, 24(2):84-90, 2011
Journal Title
Journal of geriatric psychiatry and neurology
ISSN
0891-9887
Abstract
We investigated the associations of periventricular white matter hyperintensities (PWMHs) and deep white matter hyperintensities (DWMHs) with cognition, activities of daily living (ADLs), and neuropsychiatric symptoms in dementia. This was a hospital-based MRI300 study. We recruited patients newly diagnosed with mild-to-moderate dementia caused either by Alzheimer's disease or subcortical ischemic vascular dementia from 13 dementia clinics at university or general hospitals in South Korea. We enrolled 289 patients aged over 50 from August 2007 to March 2008. We compared cognition, ADLs, and neuropsychiatric symptoms among 3 groups according to the severities of PWMHs and DWMHs, respectively, by adjusting for age, vascular risk factors, and level of other WMHs. A higher severity of PWMHs was related to lower cognitive function and severer neuropsychiatric symptoms, whereas basic ADLs were associated with DWMH. Both PWMHs and DWMHs exhibited different associations with cognition, neuropsychiatric symptoms, and daily activities.
MeSH terms
*Activities of Daily LivingAgedAged, 80 and overAnalysis of VarianceBrain/*pathology/physiopathologyCognition/*physiologyCognition Disorders/complications/pathology/physiopathologyDementia/complications/*pathology/*physiopathologyFemaleHumansMaleNerve Fibers, Myelinated/*pathology/physiologyNeuropsychological TestsRisk Factors
DOI
10.1177/0891988711402351
PMID
21546648
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
문, 소영
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