89 306

Cited 77 times in

Outcomes and prognostic factors of intracranial unruptured vertebrobasilar artery dissection.

Kim, BM; Kim, SH; Kim, DI; Shin, YS; Suh, SH; Kim, DJ; Park, SI; Park, KY; Ahn, SS
Neurology, 76(20):1735-1741, 2011
Journal Title
OBJECTIVE: We aimed to evaluate the long-term clinical outcomes and prognostic factors of symptomatic intracranial unruptured vertebrobasilar artery dissection (siu-VBD).

METHODS: A total of 191 patients (M:F = 127:64; median age, 46 years) with siu-VBD were treated between January 2001 and December 2008. Presentations, treatments, outcomes, and prognostic factors were retrospectively analyzed.

RESULTS: Clinical manifestations were ischemic symptoms with headache (n = 97) or without headache (n = 13) and headache without ischemic symptoms (n = 81). Forty-six patients (24.1%) underwent endovascular treatment. The remaining 145 patients (75.9%) were medically treated with anticoagulants (n = 49), antiplatelets (n = 48), or analgesics alone (n = 48). Clinical follow-up data were available in 178 patients (102 ischemic and 76 nonischemic) at 15 to 102 months (mean, 46 months). None of the siu-VBD hemorrhaged. All 76 patients without ischemic presentation had favorable outcomes (modified Rankin Scale, 0-1). Of the 102 patients with ischemic presentation, outcomes were favorable in 92 and unfavorable in 10 patients. Four patients died; 3 died of causes unrelated to VBD, and one died as a result of basilar artery (BA) dissection. Old age (odds ratio [OR] 1.099; 95% confidence interval [CI] 1.103-1.204; p = 0.042) and BA involvement (OR 11.886; 95% CI 1.416-99.794; p = 0.023) were independent predictors of unfavorable outcomes in siu-VBD with ischemic presentation.

CONCLUSIONS: Clinical outcomes for siu-VBD were favorable in all patients without ischemic symptoms and in most patients with ischemic presentation. None of the siu-VBD caused subarachnoid hemorrhage. Old age and BA involvement were independent predictors of unfavorable outcome in siu-VBD with ischemic presentation.
MeSH terms
AdultAnalgesics/therapeutic useAnticoagulants/therapeutic useCerebral AngiographyDiffusion Magnetic Resonance ImagingEndovascular ProceduresFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIntracranial Aneurysm/diagnosis/surgery/*therapyMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedPlatelet Aggregation Inhibitors/therapeutic usePrognosisRisk FactorsTomography, X-Ray ComputedTreatment OutcomeVertebral Artery Dissection/diagnosis/surgery/*therapyVertebrobasilar Insufficiency/diagnosis/surgery/*therapy
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
AJOU Authors
김, 세혁
Full Text Link
Files in This Item:
fulltext not available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.