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Immunoglobulin G4-related hypertrophic pachymeningitis involving cerebral parenchyma.

Authors
Kim, EH; Kim, SH; Cho, JM; Ahn, JY; Chang, JH
Citation
Journal of neurosurgery, 115(6):1242-1247, 2011
Journal Title
Journal of neurosurgery
ISSN
0022-30851933-0693
Abstract
The authors report a case of IgG4-related hypertrophic pachymeningitis that involved cerebral parenchyma. The mass was removed surgically. Histopathological studies showed diffuse infiltration of lymphoplasmacytic cells without evidence of Langerhans histiocytes or meningothelial cells. Immunoglobulin G4 was strongly positive on immunohistochemical staining. The Gd-enhanced lesion deep inside brain parenchyma was completely resolved after 3 months of oral corticosteroid medication. A nodular type of hypertrophic pachymeningitis that mimics a meningioma is rare. Nevertheless, preoperative presumption is very important, and immunohistochemical studies for IgG4 may be helpful in the differential diagnosis.
MeSH terms
Adrenal Cortex Hormones/therapeutic useAdultDiagnosis, DifferentialDura Mater/*immunology/metabolism/*pathologyHumansHypertrophy/drug therapy/immunology/pathology/surgeryImmunoglobulin G/*immunology/metabolismImmunohistochemistryMaleMeningitis/drug therapy/*immunology/*pathology/surgeryRemission Induction
DOI
10.3171/2011.7.JNS1166
PMID
21854114
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
AJOU Authors
조, 진모
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