Cited 0 times in Scipus Cited Count

Immunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non-granulomatous rosacea.

DC Field Value Language
dc.contributor.authorJang, YH-
dc.contributor.authorSim, JH-
dc.contributor.authorKang, HY-
dc.contributor.authorKim, YC-
dc.contributor.authorLee, ES-
dc.date.accessioned2012-05-08T01:31:40Z-
dc.date.available2012-05-08T01:31:40Z-
dc.date.issued2011-
dc.identifier.issn0926-9959-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6833-
dc.description.abstractBACKGROUND: There is a granulomatous variant which is recognized in the rosacea spectrum. However, the pathogenesis of granuloma formation in rosacea has not been clearly demonstrated. Matrix metalloproteinases (MMPs) are required for recruitment of inflammatory cells and for tissue remodelling, making way for the development of well-organized granuloma.



OBJECTIVE: The aim of this study was to investigate the expression of transforming growth factor (TGF)-β, TGF-β type II receptor (TβRII), Tumour necrosis factor (TNF)-α, MMP-1, 2 and 9 in the granulomatous rosacea (GR) compared with the non-granulomatous rosacea (NGR) and test the hypothesis that the changes of these profiles in GR would be related with chronic ultraviolet radiation (UVR)-exposure.



METHODS: Facial skin samples were obtained from 20 patients with GR and NGR (control group). The sections were stained using haematoxylin and eosin, Verhoeff's elastic stain, and antibodies to TGF-β, TβRII, TNF-α, MMP-1, -2 and -9.



RESULTS: The amount of elastotic material was significantly increased in the dermis of GR lesions. Expression of TGF-β was significantly decreased in the epidermis of GR lesions compared with NGR lesions. In addition, the expression of MMP-9 was significantly increased in the dermis of GR lesions compared with NGR lesions, especially at the centre of the granuloma on a semi-quantitative analysis. MMP-2 expression was also increased in GR lesions, although the difference between the two groups was not statistically significant.



CONCLUSIONS: The results of this study suggest that the increased expression of MMPs in the dermis may participate in granuloma formation of GR in association with UVR.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHEnvironmental Exposure-
dc.subject.MESHFacial Dermatoses-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 1-
dc.subject.MESHMatrix Metalloproteinase 2-
dc.subject.MESHMatrix Metalloproteinase 9-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProtein-Serine-Threonine Kinases-
dc.subject.MESHReceptors, Transforming Growth Factor beta-
dc.subject.MESHRosacea-
dc.subject.MESHSkin-
dc.subject.MESHTime Factors-
dc.subject.MESHTransforming Growth Factor beta-
dc.subject.MESHTumor Necrosis Factor-alpha-
dc.subject.MESHUltraviolet Rays-
dc.subject.MESHYoung Adult-
dc.titleImmunohistochemical expression of matrix metalloproteinases in the granulomatous rosacea compared with the non-granulomatous rosacea.-
dc.typeArticle-
dc.identifier.pmid20698913-
dc.contributor.affiliatedAuthor강, 희영-
dc.contributor.affiliatedAuthor김, 유찬-
dc.contributor.affiliatedAuthor이, 은소-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1468-3083.2010.03825.x-
dc.citation.titleJournal of the European Academy of Dermatology and Venereology : JEADV-
dc.citation.volume25-
dc.citation.number5-
dc.citation.date2011-
dc.citation.startPage544-
dc.citation.endPage548-
dc.identifier.bibliographicCitationJournal of the European Academy of Dermatology and Venereology : JEADV, 25(5). : 544-548, 2011-
dc.identifier.eissn1468-3083-
dc.relation.journalidJ009269959-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse