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A multicenter study on extramammary Paget's disease in Korea.

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dc.contributor.authorLee, SJ-
dc.contributor.authorChoe, YS-
dc.contributor.authorJung, HD-
dc.contributor.authorAhn, SK-
dc.contributor.authorCha, YC-
dc.contributor.authorCho, KH-
dc.contributor.authorChoi, HY-
dc.contributor.authorChung, KY-
dc.contributor.authorHuh, CH-
dc.contributor.authorKim, IH-
dc.contributor.authorKim, KH-
dc.contributor.authorKim, MB-
dc.contributor.authorKim, MH-
dc.contributor.authorKim, YC-
dc.contributor.authorLee, JB-
dc.contributor.authorLee, MW-
dc.contributor.authorLee, MG-
dc.contributor.authorLee, WJ-
dc.contributor.authorShin, DH-
dc.contributor.authorShin, JH-
dc.contributor.authorSuh, KS-
dc.contributor.authorWon, YH-
dc.contributor.authorKorean Society for Skin Cancer and Korean Dermatopathology Research Group-
dc.date.accessioned2012-05-08T01:38:22Z-
dc.date.available2012-05-08T01:38:22Z-
dc.date.issued2011-
dc.identifier.issn0011-9059-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6835-
dc.description.abstractBACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia.



METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period.



RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%).



CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHColonic Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMohs Surgery-
dc.subject.MESHMulticenter Studies as Topic-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHPaget Disease, Extramammary-
dc.subject.MESHRectal Neoplasms-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSex Factors-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleA multicenter study on extramammary Paget's disease in Korea.-
dc.typeArticle-
dc.identifier.pmid21506963-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2011&volume=50&issue=5&spage=508-
dc.contributor.affiliatedAuthor김, 유찬-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1365-4632.2010.04661.x-
dc.citation.titleInternational journal of dermatology-
dc.citation.volume50-
dc.citation.number5-
dc.citation.date2011-
dc.citation.startPage508-
dc.citation.endPage515-
dc.identifier.bibliographicCitationInternational journal of dermatology, 50(5). : 508-515, 2011-
dc.identifier.eissn1365-4632-
dc.relation.journalidJ000119059-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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