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Transcriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.

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dc.contributor.authorKang, HY-
dc.contributor.authorSuzuki, I-
dc.contributor.authorLee, DJ-
dc.contributor.authorHa, J-
dc.contributor.authorReiniche, P-
dc.contributor.authorAubert, J-
dc.contributor.authorDeret, S-
dc.contributor.authorZugaj, D-
dc.contributor.authorVoegel, JJ-
dc.contributor.authorOrtonne, JP-
dc.date.accessioned2012-05-08T01:51:38Z-
dc.date.available2012-05-08T01:51:38Z-
dc.date.issued2011-
dc.identifier.issn0022-202X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6838-
dc.description.abstractMelasma is a commonly acquired hyperpigmentary disorder of the face, but its pathogenesis is poorly understood and its treatment remains challenging. We conducted a comparative histological study on lesional and perilesional normal skin to clarify the histological nature of melasma. Significantly, higher amounts of melanin and of melanogenesis-associated proteins were observed in the epidermis of lesional skin, and the mRNA level of tyrosinase-related protein 1 was higher in lesional skin, indicating regulation at the mRNA level. However, melanocyte numbers were comparable between lesional and perilesional skin. A transcriptomic study was undertaken to identify genes involved in the pathology of melasma. A total of 279 genes were found to be differentially expressed in lesional and perilesional skin. As was expected, the mRNA levels of a number of known melanogenesis-associated genes, such as tyrosinase, were found to be elevated in lesional skin. Bioinformatics analysis revealed that the most lipid metabolism-associated genes were downregulated in lesional skin, and this finding was supported by an impaired barrier function in melasma. Interestingly, a subset of Wnt signaling modulators, including Wnt inhibitory factor 1, secreted frizzled-related protein 2, and Wnt5a, were also found to be upregulated in lesional skin. Immunohistochemistry confirmed the higher expression of these factors in melasma lesions.-
dc.language.isoen-
dc.subject.MESHAdaptor Proteins, Signal Transducing-
dc.subject.MESHAdult-
dc.subject.MESHFrizzled Receptors-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHLipid Metabolism-
dc.subject.MESHMelanocytes-
dc.subject.MESHMelanosis-
dc.subject.MESHMembrane Glycoproteins-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOxidoreductases-
dc.subject.MESHProto-Oncogene Proteins-
dc.subject.MESHReceptors, G-Protein-Coupled-
dc.subject.MESHRepressor Proteins-
dc.subject.MESHWnt Proteins-
dc.subject.MESHWnt1 Protein-
dc.titleTranscriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.-
dc.typeArticle-
dc.identifier.pmid21562572-
dc.contributor.affiliatedAuthor강, 희영-
dc.type.localJournal Papers-
dc.identifier.doi10.1038/jid.2011.109-
dc.citation.titleThe Journal of investigative dermatology-
dc.citation.volume131-
dc.citation.number8-
dc.citation.date2011-
dc.citation.startPage1692-
dc.citation.endPage1700-
dc.identifier.bibliographicCitationThe Journal of investigative dermatology, 131(8). : 1692-1700, 2011-
dc.identifier.eissn1523-1747-
dc.relation.journalidJ00022202X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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