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Skin rejuvenating effects of chemical peeling: a study in photoaged hairless mice.

DC Field Value Language
dc.contributor.authorHan, SH-
dc.contributor.authorKim, HJ-
dc.contributor.authorKim, SY-
dc.contributor.authorKim, YC-
dc.contributor.authorChoi, GS-
dc.contributor.authorShin, JH-
dc.date.accessioned2012-05-08T02:03:57Z-
dc.date.available2012-05-08T02:03:57Z-
dc.date.issued2011-
dc.identifier.issn0011-9059-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6842-
dc.description.abstractBackground  Chemical peeling is a dermatologic treatment for skin aging. However, the mechanism by which the chemical peel achieves its results is not clear. We investigated the effects of chemical peeling and the mechanism of wrinkle reduction in photoaged hairless mice skin. Methods  After inducing photoaged skin in hairless mice by repetitive ultraviolet-B irradiation applied over 14 weeks, we applied trichloroacetic acid (TCA) 30%, TCA 50%, and phenol on areas of the same size on the backs of the mice. Punch biopsies were obtained 7, 14, 28, and 60 days after the procedure for histologic and immunohistochemical analyses. Results  Histologic examination showed an increase in dermal thickness, collagen fibers, and elastic fibers in the dermis of intervention groups compared with control groups. These increases were maintained significantly for 60 days. Conclusions  This study demonstrates that chemical peeling reduces wrinkles and regenerates skin by increasing dermal thickness and the amount of collagen and elastic fibers in photoaged skin.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESH*Chemexfoliation-
dc.subject.MESHCollagen/metabolism-
dc.subject.MESHElastic Tissue/pathology-
dc.subject.MESHMice-
dc.subject.MESHMice, Hairless-
dc.subject.MESHPhenol/administration & dosage-
dc.subject.MESH*Rejuvenation-
dc.subject.MESHSkin/metabolism/pathology-
dc.subject.MESH*Skin Aging-
dc.subject.MESHTrichloroacetic Acid/administration & dosage-
dc.titleSkin rejuvenating effects of chemical peeling: a study in photoaged hairless mice.-
dc.typeArticle-
dc.identifier.pmid22126868-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0011-9059&date=2011&volume=50&issue=9&spage=1075-
dc.contributor.affiliatedAuthor김, 유찬-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1365-4632.2010.04712.x-
dc.citation.titleInternational journal of dermatology-
dc.citation.volume50-
dc.citation.number9-
dc.citation.date2011-
dc.citation.startPage1075-
dc.citation.endPage1082-
dc.identifier.bibliographicCitationInternational journal of dermatology, 50(9):1075-1082, 2011-
dc.identifier.eissn1365-4632-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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