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Management of endometrial hyperplasia with a levonorgestrel-releasing intrauterine system: single arm, prospective multicenter study: Korean gynecologic oncology group study (KGOG2006).

Authors
Lee, TS; Seong, SJ; Kim, JW; Ryu, HS; Song, ES; Nam, BH
Citation
Japanese journal of clinical oncology, 41(6):817-819, 2011
Journal Title
Japanese journal of clinical oncology
ISSN
0368-28111465-3621
Abstract
A prospective multicenter trial has been commenced in Korea to investigate the treatment efficacy of the levonorgestrel-releasing intrauterine system in patients with endometrial hyperplasia. The levonorgestrel-releasing intrauterine system is an alternative to oral progesterone without the disadvantages of oral progestogens. Therefore, we hypothesize that if the therapeutic efficacy of the levonorgestrel-releasing intrauterine system is similar to or greater than that of oral progesterone, the levonorgestrel-releasing intrauterine system could become the standard treatment for endometrial hyperplasia patients who do not want a hysterectomy. The levonorgestrel-releasing intrauterine system is inserted into uteri of patients with histologically confirmed endometrial hyperplasia. An office endometrial aspiration biopsy and transvaginal ultrasound are conducted every 3 months at an outpatients clinic. The primary endpoint is the response rate. The secondary endpoint is to estimate the consistency of the results of the office endometrial aspiration biopsy during the levonorgestrel-releasing intrauterine system being placed in uterus and a dilatation and curettage procedure.
MeSH terms
AdultAgedBiopsy, NeedleContraceptive Agents, Female/administration & dosageEndometrial Hyperplasia/*drug therapy/pathology/ultrasonographyFemaleHumans*Intrauterine Devices, MedicatedLevonorgestrel/*administration & dosageMiddle AgedPatient SelectionProspective StudiesRepublic of KoreaTreatment Outcome
DOI
10.1093/jjco/hyr048
PMID
21478178
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
AJOU Authors
유, 희석
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