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Prevalence of vitamin D deficiency and clinical efficacy of vitamin D supplementation in patients with atopic dermatitis

Nahm, Dong-Ho; Kim, Myoung-Eun; Shin, Yoo-Seob; Ye, Young-Min; Park, Hae-Sim
Department of Allergy & Clinical Immunology, Ajou University School of Medicine
BACKGROUND: Vitamin D deficiency was associated with increased prevalence of atopic dermatitis (AD). Vitamin D supplementation resulted in significant clinical improvements in patients with AD in a few studies. We evaluated the the prevalence of vitamin D deficiency and the clinical efficacy of vitamin D supplementation in patients with AD.
METHOD: Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured by radio-immunoassay in 102 patients with AD (mean age: 23.2 years, range 4 – 64 years). Vitamin D deficiency was defined when serum levels of 25(OH)D were less than 20 ng/ml. Fourteen adult patients with AD were supplemented with 2,000 IU of vitamin D (cholecalciferol) daily for 2 months.
RESULTS: Vitamin D deficiency was observed 88 (86.3%) of 102 patients with AD. After supplementation of vitamin D, the clinical severity score of atopic dermatitis (SCORAD) significantly decreased from 45.2 ± 27.6 (mean ± SD) at baseline to 30.3 ± 20.5 at 2 months in 14 patients with AD (p = 0.01). Mean decrease in SCORAD value at 2 months compared to baseline value was 28.0%. Serum levels of 2 (OH)D were significantly increased from 12.4 ± 5.3 to 26.6 ± 7.8 after supplementation of vitamin D (p = 0.001). There was no siginificant changes in peripheral blood eosinophil counts before (414.7 ± 258.9) and after (351.6 ± 212.2) supplementation of vitamin D (p >0.05).
CONCLUSION: Vitamin D deficiency was prevalent in patients with AD and vitamin D supplementation resulted in significant clinical improvements.
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