0 134

Cited 0 times in

Clinical significance of serum specific IgE to component allergen in the patients with wheat allergy

Authors
Hwang, Eui-Kyung; Nam, Young-Hee; Jin, Hyun Jung; Yoo, Hye-Soo; Lee, Jeong-Min; Shin, Yoo Seob; Ye, Young-Min; Palacin, A.; Salcedo, G.; Lee, Soo-Young; Park, Hae-Sim
Department
Department of Allergy & Clinical Immunology
Abstract
Background: To evaluate clinical significance of specific IgE(sIgE) response to component allergens in two phenotypes of wheat allergy.



Methods: 29 patients with wheat allergy were enrolled and divided into two groups, 21 patients with food allergy(group I) and 8 patients with respiratory allergy(group II), and compared with 11 patients with buckwheat induced food allergy(group III). The sIgE levels to wheat, ω-5 gliadin and common carbohydrate determinant(CCD) were measured by immunoCAP, and sIgE to Tri a 14 was measured by ELISA.



Results: The subjects in group I had significantly higher serum sIgE ratio of ω-5 gliadin to wheat, but lower sIgE ratio of Tri a 14 to ω-5 gliadin than in group II (P=.008, P<.001). The sIgE to CCD was detectable in 21% of group I, while no one in group II. In group III, 33.3% those having sIgE to wheat had high sIgE to CCD. Significant correlation was found between level of sIgE to wheat and CCD (r=.738 P=.023).



Conclusion: Measurement of serum sIgE to wheat component allergen may be useful for differentiating two major phenotypes of wheat allergy.
Appears in Collections:
Others > Poster > Poster
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse