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Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.
DC Field | Value | Language |
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dc.contributor.author | Kim, SH | - |
dc.contributor.author | Cho, BY | - |
dc.contributor.author | Park, CS | - |
dc.contributor.author | Shin, ES | - |
dc.contributor.author | Cho, EY | - |
dc.contributor.author | Yang, EM | - |
dc.contributor.author | Kim, CW | - |
dc.contributor.author | Hong, CS | - |
dc.contributor.author | Lee, JE | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-20T05:48:20Z | - |
dc.date.available | 2010-12-20T05:48:20Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/703 | - |
dc.description.abstract | BACKGROUND: Toluene diisocyanate (TDI) is the most important cause of occupational asthma, but the genetic mechanism of TDI-induced asthma is still unknown.
OBJECTIVE: The objective of the study was to identify susceptibility alleles associated with the TDI-induced asthma phenotype. METHODS: We conducted a genome-wide association study in 84 patients with TDI-induced asthma and 263 unexposed healthy normal controls using Affymetrix 500K SNPchip. We also investigated the relationships between genetic polymorphisms and transcript levels in Epstein-Barr virus-transformed lymphoblastoid cell lines from patients with TDI-induced asthma enrolled in this study. RESULTS: Genetic polymorphisms of CTNNA3 (catenin alpha 3, alpha-T catenin) were significantly associated with the TDI-induced asthma phenotype (5.84 x 10(-6) for rs10762058, 1.41 x 10(-5) for rs7088181, 2.03 x 10(-5) for rs4378283). Carriers with the minor haplotype, HT2 [GG], of two genetic polymorphisms (rs10762058 and rs7088181) showed significantly lower PC(20) methacholine level (P=0.041) and lower mRNA expression of CTNNA3 than non-carriers (P=0.040). A genetic polymorphism in the 3' downstream region of CTNNA3 (rs1786929), as identified by DNA direct sequencing, was significantly associated with the TDI-induced asthma phenotype (P=0.015 in recessive analysis model) and the prevalence of serum-specific IgG to cytokeratin 19 (P=0.031). CONCLUSION: These findings suggested that multiple genetic polymorphisms of CTNNA3 may be determinants of susceptibility to TDI-induced asthma. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | B-Lymphocytes | - |
dc.subject.MESH | Bronchial Provocation Tests | - |
dc.subject.MESH | Cell Line, Transformed | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Immunoglobulin G | - |
dc.subject.MESH | Keratin-19 | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Occupational Diseases | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate | - |
dc.subject.MESH | alpha Catenin | - |
dc.title | Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis. | - |
dc.type | Article | - |
dc.identifier.pmid | 19187332 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2009&volume=39&issue=2&spage=203 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1111/j.1365-2222.2008.03117.x | - |
dc.citation.title | Clinical and experimental allergy | - |
dc.citation.volume | 39 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 203 | - |
dc.citation.endPage | 212 | - |
dc.identifier.bibliographicCitation | Clinical and experimental allergy, 39(2). : 203-212, 2009 | - |
dc.identifier.eissn | 1365-2222 | - |
dc.relation.journalid | J009547894 | - |
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