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Risk factors for contraindicated co-prescription - In elderly patients

Ahn, Eun Kyoung; Park, Rae Woong
Department of Medical Informatics
The purpose of this study is to reveal the risk factors associated with co-medication of contraindicated drugs in hospitalized elderly patients. Elderly patients hospitalized to a Korean tertiary teaching hospital was enrolled to the study for 18 months. All prescriptions were monitored by a drug-drug interaction (DDI) alert system. We found that female sex, longer hospitalization, number of diagnoses and number of drugs per day were related to the co-medication of contraindicated drugs in the elderly. The most frequent pair was double medication with anti-inflammatory and anti-rheumatic product. Listed combination of frequently co-prescribed drugs, the combination of which are contraindicated, should be closely monitored to prevent possible adverse drug events.
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