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Intra-arterial delivery of the mesenchymal stem cells to ischemic rat brain

kim, Geuhee; Shin, Dong Hoon; Lee, Young-Don; Hong, Jiman; Kim, Sung-Soo; Suh-Kim, Haeyoung
Department of Anatomy, Ajou University School of Medicine; Department of Neurology, Ajou University School of Medicine
Mesenchymal stem cells (MSCs) have been shown to improve a variety of neurological dysfunction by their paracrine effects. Previously, we showed that most therapeutic functions of MSCs are dependent on their paracrine functions in a rat stroke model. We also showed that intracranial transplantation of neuronally induced MSCs with Neurogenin-1 (Ngn1), a developmental regulator of the nervous system, markedly improved motor functions through transdifferentiating into neurons. However, intracranial injection of stem cells to the ischemic brain is invasive, and, thus, unable to be applicable to some stroke patients. In this study, we established a less invasive method to deliver MSCs through the internal carotid artery and evaluated whether therapeutic outcome is comparable to that of intracranial transplantation.
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