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Longitudinal strain and torsion assessed by two-dimensional speckle tracking correlate with the serum level of tissue inhibitor of matrix metalloproteinase-1, a marker of myocardial fibrosis, in patients with hypertension.

Authors
Kang, SJ; Lim, HS; Choi, BJ; Choi, SY; Hwang, GS; Yoon, MH; Tahk, SJ; Shin, JH
Citation
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 21(8):907-911, 2008
Journal Title
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
ISSN
0894-73171097-6795
Abstract
BACKGROUND: We hypothesized that the alterations of myocardial collagen turnover in patients with hypertension may be involved in the early changes of regional contractile function assessed by a new speckle tracking method.



METHODS: In 56 patients with untreated hypertension (48 +/- 11 years, ejection fraction > 55%) and 20 age-matched control subjects, the serum levels of aminoterminal propeptide of procollagen I/III and tissue inhibitor of matrix metalloproteinase (TIMP)-1 were measured by radioimmunoassay and enzyme immunoassay. To assess the regional contractile function, the average of negative longitudinal strain of 6 segments at apical 4-chamber view (longitudinal epsilon), the average of radial strain (radial epsilon) and the average of circumferential strain (circumferential epsilon) of 6 mid-left ventricular (LV) segments, and basal-to-apical torsion were obtained by 2-dimensional speckle tracking imaging.



RESULTS: Compared with control group, longitudinal epsilon was significantly decreased (-20.4 +/- 3.0% vs -22.1 +/- 2.2%, P = .030) and basal-to-apical torsion was increased (20.5 +/- 5.7 degrees vs 17.4 +/- 3.7 degrees, P = .013) in patient group. The serum level of log TIMP-1 was higher in the patients (3.6 +/- 0.6 vs 3.0 +/- 0.5, P < .001). The serum log TIMP-1 significantly correlated with longitudinal epsilon (r = 0.405, P = .015), basal-to-apical torsion (r = 0.331, P = .017), and the LV mass (r = 0.266, P = .047). In multivariate analysis, longitudinal epsilon (beta = 0.326, P = .015) and basal-to-apical torsion (beta = 0.402, P = .003) independently correlated with the serum TIMP-1 level.



CONCLUSION: In patients who are hypertensive with normal ejection fraction, impaired longitudinal epsilon and increased LV torsion correlated with serum TIMP-1, which suggests that the change in collagen turnover and the myocardial fibrotic process may affect the early contractile dysfunction of LV.
MeSH terms
Echocardiography/methods*Elasticity Imaging Techniques/methods*Endomyocardial Fibrosis/blood*Endomyocardial Fibrosis/ultrasonography*FemaleHumansHypertension/blood*MaleMatrix Metalloproteinase 1/blood*Middle AgedReproducibility of ResultsSensitivity and SpecificityStatistics as TopicTorsion Abnormality/blood*Torsion Abnormality/ultrasonography*Ventricular Dysfunction, Left/bloodVentricular Dysfunction, Left/ultrasonography
DOI
10.1016/j.echo.2008.01.015
PMID
18325736
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
강, 수진임, 홍석최, 병주최, 소연황, 교승윤, 명호탁, 승제신, 준한
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