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Short-term administration of water-soluble silicon improves mineral density of the femur and tibia in ovariectomized rats.

Authors
Bae, YJ; Kim, JY; Choi, MK; Chung, YS; Kim, MH
Citation
Biological trace element research, 124(2):157-163, 2008
Journal Title
Biological trace element research
ISSN
0163-49841559-0720
Abstract
Silicon is important for the proper growth and development of bone and connective tissues. This study was designed to investigate if water-soluble silicon could be used for the treatment of postmenopausal osteoporosis. Silicon (Si 20 mg/kg body weight/day) was administrated orally to 17-week-old ovariectomized (OVX) rats for 4 weeks. Silicon did not alter weight gain in OVX rats. Silicon supplementation significantly increased the bone mineral density of the femur (p < 0.05, vs. OVX control group) and tibia in OVX rats (p < 0.05, vs. OVX control group). Serum alkaline phosphatase and osteocalcin, two bone formation biomarkers tested, were not significantly altered, but urinary calcium and phosphorous excretion tended to decrease with silicon supplementation. OVX rats with silicon supplementation showed a relatively higher serum CTx compared to the nonsupplemented OVX group (p < 0.01, vs. OVX control group). According to these results, short-term soluble silicon supplementation improved bone mineral density in OVX-induced osteoporosis.
MeSH terms
Alkaline Phosphatase/bloodAnimalsBiological Markers/bloodBone Density/drug effects*Calcium/urineDietary Supplements*Disease Models, AnimalFemur/metabolism*HumansMaleOsteocalcin/bloodOsteoporosis, Postmenopausal/blood*Osteoporosis, Postmenopausal/diet therapyOsteoporosis, Postmenopausal/urineOvariectomyRatsRats, Sprague-DawleySilicon/pharmacology*SolubilityTibia/metabolism*
DOI
10.1007/s12011-008-8138-3
PMID
18438624
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
정윤석
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