194 347

Cited 18 times in

Short-term administration of water-soluble silicon improves mineral density of the femur and tibia in ovariectomized rats.

Bae, YJ; Kim, JY; Choi, MK; Chung, YS; Kim, MH
Biological trace element research, 124(2):157-163, 2008
Journal Title
Biological trace element research
Silicon is important for the proper growth and development of bone and connective tissues. This study was designed to investigate if water-soluble silicon could be used for the treatment of postmenopausal osteoporosis. Silicon (Si 20 mg/kg body weight/day) was administrated orally to 17-week-old ovariectomized (OVX) rats for 4 weeks. Silicon did not alter weight gain in OVX rats. Silicon supplementation significantly increased the bone mineral density of the femur (p < 0.05, vs. OVX control group) and tibia in OVX rats (p < 0.05, vs. OVX control group). Serum alkaline phosphatase and osteocalcin, two bone formation biomarkers tested, were not significantly altered, but urinary calcium and phosphorous excretion tended to decrease with silicon supplementation. OVX rats with silicon supplementation showed a relatively higher serum CTx compared to the nonsupplemented OVX group (p < 0.01, vs. OVX control group). According to these results, short-term soluble silicon supplementation improved bone mineral density in OVX-induced osteoporosis.
MeSH terms
Alkaline Phosphatase/bloodAnimalsBiological Markers/bloodBone Density/drug effects*Calcium/urineDietary Supplements*Disease Models, AnimalFemur/metabolism*HumansMaleOsteocalcin/bloodOsteoporosis, Postmenopausal/blood*Osteoporosis, Postmenopausal/diet therapyOsteoporosis, Postmenopausal/urineOvariectomyRatsRats, Sprague-DawleySilicon/pharmacology*SolubilityTibia/metabolism*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
정, 윤석
Files in This Item:
Full-Text Not Available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.