G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome
기능성 소화 불량증 및 과민성 장 증후군의 중복 증후군 환자에서 G-Protein Beta3 C825T 유전자 다형성
Background: G-protein beta3 subunit (GNB3) C825T polymorphism alters intracellular signal transduction, which may lead to motor or sensory abnormalities of the gastrointestinal tract. The aim of the present study was to evaluate the association of the GNB3 C825T polymorphism with susceptibility to overlap syndrome of functional dyspepsia (FD) and irritable bowel syndrome (IBS) in a Korean population.
Methods: One hundred sixty-seven patients with FD alone, 60 patients with IBS alone, 85 patients with the overlap of FD and IBS, and 434 asymptomatic healthy subjects participated in the study. Genotyping for GNB3 C825T polymorphism was performed using their blood samples.
Results: No association of genotype in subjects with FD alone, IBS alone or overlap phenotype compared to that in controls was detected. The frequency of GNB3 C825T CT and TT genotypes relative to the CC genotype for the phenotypes of FD alone, IBS alone, and the coexistence of FD and IBS did not significantly differ. Comparison of the TT genotype with the CC/CT genotype showed no significant association for each phenotype group.
Conclusions: There is no apparent association of the GNB3 C825T polymorphism with the susceptibility to FD, IBS or the overlap of FD and IBS. A larger-scale study and further investigation on other candidate genes are required.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,779,577
Total Download :1,134,052
Today View :2,395
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.