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Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis

DC Field Value Language
dc.contributor.author김, 동훈-
dc.date.accessioned2012-10-31T04:18:09Z-
dc.date.available2012-10-31T04:18:09Z-
dc.date.issued2012-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7593-
dc.description.abstractBackground: Add on adefovir (ADV) to ongoing lamivudine (LAM) is an established treatment modality for treatment of LAM resistance with chronic hepatitis B. We assessed the long?term efficacy (median follow-up of 20.18 months) of ADV add-on LAM therapy in 89 LAM-resistant patients.

Methods: 89 patients (29.2% cirrhotics, 76.4% hepatitis B e antigen positive) with LAM resistant patients who were not experienced ADV monotherapy were enrolled, retrospectively from August 2005 to October 2010. All the patients were treated with ADV add-on LAM therapy. Liver function test, hepatitis B virus (HBV) DNA and HBeAg/HBeAb were assessed every 3 months. ADV associated (rtA181T/V and rtN236T) mutations were looked for at intervals in all HBV DNA-positive serum samples, yearly

Results: Cumulative ratio of undetectable HBV DNA level (<50 copies/mL or <8.6 IU/mL) at 6 months, 1 year, and 2 years were 15.7%/44.2%/45.4% for HBeAg positive group and 34.8%/39.1%/52.6% in HBeAg negative group. Seroconversion was observed 10.2%/19.7%/23.6% in 6 months, 1 year, and 2 years. Virologic breakthrough phenomenon was seen 1.1%.

Conclusions: LAM and ADV combination therapy effectively suppresses HBV replication and prevents virologic and clinical breakthrough in LMV-resistant patients. And emergence of ADV-resistant mutants is rare, at least over a period of 24 months.
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dc.description.tableofcontents국문요약

차례

그림 차례

표 차례

Ⅰ. 서론 1

Ⅱ. 연구대상 및 방법 3

A. 연구대상 3

B. 연구방법 3

C. 통계 4

Ⅲ. 결과 5

A. 대상 환자군의 치료 전 특성 5

B. 치료 반응 6

C. 바이러스 돌파 현상의 관찰 9

D. 유전자형 내성 빈도의 관찰 10

Ⅳ. 고찰 14

Ⅴ. 결론 17

참고문헌 18

ABSTRACT 22
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dc.language.isoko-
dc.titleAnalysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis-
dc.title.alternative라미부딘 내성 만성 B형 간염 환자에 있어 라미부딘과 아데포비어 병용 요법의 치료 효과와 특성 분석-
dc.typeThesis-
dc.identifier.urlhttp://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012181-
dc.subject.keyword만성 B형 간염-
dc.subject.keyword라미부딘 내성-
dc.subject.keyword아데포비어-
dc.subject.keyword바이러스 돌파-
dc.description.degreeMaster-
dc.contributor.department대학원 의학과-
dc.contributor.affiliatedAuthor김, 동훈-
dc.date.awarded2012-
dc.type.localTheses-
dc.citation.date2012-
Appears in Collections:
Theses > School of Medicine / Graduate School of Medicine > Master
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