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Immunological investigation in the adenoid tissues from children with chronic rhinosinusitis.

Authors
Shin, SY; Choi, GS; Park, HS; Lee, KH; Kim, SW; Cho, JS
Citation
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 141(1):91-96, 2009
Journal Title
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN
0194-59981097-6817
Abstract
OBJECTIVE: Chronic rhinosinusitis (CRS) is characterized by persistent inflammation and tissue remodeling of the nasal mucosa. Adenoidectomy is an effective surgical treatment in pediatric CRS. To evaluate the effect of pediatric CRS on the severity and characteristics of adenoid inflammation, the authors evaluated the expressions of inflammatory cell activation markers and tissue remodeling in adenoid tissues associated with cytokines tissue-remodeling-associated cytokines in adenoid tissues. STUDY DESIGN AND SETTING: A prospective controlled study on 40 pediatric patients admitting for adenotonsillectomy. SUBJECTS AND METHODS: Immunoassays were performed on adenoid tissues homogenates from 16 children with CRS and from 24 children without CRS to quantify the levels of inflammatory cell activation markers, such as soluble interleukin (IL)-2 receptor (sIL-2R), soluble CD23 (sCD23), IL-6, eosinophilic cationic protein (ECP), and tryptase, and the levels of cytokines associated with tissue remodeling, such as transforming growth factor (TGF)-beta1, matrix metalloproteinase (MMP) 2 and 9, and tissue inhibitor of metalloproteinase (TIMP)-1. RESULTS: The mean levels (the ratio to albumin level) of sIL-2R, TGF-beta1, MMP-2, MMP-9, and TIMP-1 were significantly higher in adenoid tissues of patients with CRS (27.31+/-30.32, 4894.65+/-2388.77, 500.13+/-604.59, and 23.06+/-10.37, respectively) than those without it (16.27+/-10.93, 2635.51+/-1448.63, 120.87+/-321.50, 16.74+/-11.10, and 7.39+/-3.12, respectively; all P<0.05). Regarding the severity of CRS, ECP level was significantly higher in patients with severe CRS than in those with mild to moderate CRS (P=0.033). CONCLUSIONS: Adenoid tissues in pediatric CRS patients had higher levels of tissue-remodeling-associated cytokines, which may explain the relationship between pediatric CRS and adenoid inflammation.
MeSH terms
Adenoids/immunology*AdolescentBiological Markers/analysis*ChildChild, PreschoolChronic DiseaseEosinophil Cationic Protein/immunologyFemaleHumansInterleukin-6/immunologyMaleMatrix Metalloproteinase 2/immunologyMatrix Metalloproteinase 9/immunologyProspective StudiesReceptors, IgE/immunologyReceptors, Interleukin-2/immunologyRhinitis/immunology*Sinusitis/immunology*Statistics, NonparametricTissue Inhibitor of Metalloproteinase-1/immunologyTransforming Growth Factor beta1/immunologyTryptases/immunology
DOI
10.1016/j.otohns.2009.03.023
PMID
19559965
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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