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The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma.
DC Field | Value | Language |
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dc.contributor.author | Choi, JH | - |
dc.contributor.author | Lee, KW | - |
dc.contributor.author | Kim, CW | - |
dc.contributor.author | Park, CS | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Hur, GY | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Hong, CS | - |
dc.contributor.author | Jang, AS | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-22T08:02:36Z | - |
dc.date.available | 2010-12-22T08:02:36Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/765 | - |
dc.description.abstract | BACKGROUND: Although the pathogenesis of toluene diisocyanate (TDI)-induced occupational asthma (TDI-OA) is incompletely understood, several studies have suggested immunologic mechanisms, including specific IgE responses. A few studies have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma in Western countries, but this is the first investigation of associations between HLA class I and II alleles and TDI-induced asthma patients in Asia, using high-resolution analysis.
METHODS: Patients with TDI-OA (n = 84), asymptomatic exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were enrolled. HLA class I and II genotyping was performed by the direct DNA sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin conjugate were measured by ELISA. RESULTS: There was no significant association between the allele frequencies and the phenotype of TDI-OA. However, the frequency of the HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype was significantly higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with statistical significance persisting after correction for multiple comparisons. DQB1*0402 was significantly associated with the presence of specific IgE to TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p value remained significant after correction for multiple comparison. CONCLUSION: The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the development of TDI-induced asthma in Koreans. Several HLA alleles that enhance specific IgE sensitization in exposed subjects are indicated. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Forced Expiratory Volume | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | HLA-DP Antigens | - |
dc.subject.MESH | HLA-DQ Antigens | - |
dc.subject.MESH | HLA-DR Antigens | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Glycoproteins | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Occupational Diseases | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Toluene 2,4-Diisocyanate | - |
dc.title | The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. | - |
dc.type | Article | - |
dc.identifier.pmid | 19439981 | - |
dc.identifier.url | http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000218118 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1159/000218118 | - |
dc.citation.title | International archives of allergy and immunology | - |
dc.citation.volume | 150 | - |
dc.citation.number | 2 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | International archives of allergy and immunology, 150(2). : 156-163, 2009 | - |
dc.identifier.eissn | 1423-0097 | - |
dc.relation.journalid | J010182438 | - |
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