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Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma.

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dc.contributor.authorHur, GY-
dc.contributor.authorKim, SH-
dc.contributor.authorPark, SM-
dc.contributor.authorYe, YM-
dc.contributor.authorKim, CW-
dc.contributor.authorJang, AS-
dc.contributor.authorPark, CS-
dc.contributor.authorHong, CS-
dc.contributor.authorPark, HS-
dc.date.accessioned2010-12-22T10:38:23Z-
dc.date.available2010-12-22T10:38:23Z-
dc.date.issued2009-
dc.identifier.issn0271-9142-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/768-
dc.description.abstractBACKGROUND: This study was conducted to evaluate whether tissue transglutaminase (tTG) may be involved in airway inflammation of toluene diisocyanate-induced occupational asthma (TDI-OA).



METHODS: We enrolled 93 patients with TDI-OA, 177 asymptomatic exposed subjects, 43 patients with allergic asthma, and 70 unexposed normal controls. The prevalence of serum immunoglobulin G (IgG) to tTG in the TDI-OA group (20.2%) was significantly higher than that in the three other groups (P < 0.001).



RESULTS: TDI-OA patients with serum IgG to tTG had significantly lower methacholine PC(20) values (P < 0.02) and significantly higher prevalence of specific immunoglobulin E to vapor type TDI-human serum albumin conjugate (P < 0.01; r(2) = 0.411, P < 0.05). TDI exposure could increase tTG activity via reactive oxygen species (ROS) production, which was found to cross-link with cytokeratin 19 on immunoblot analysis.



CONCLUSION: Therefore, TDI exposure may activate tTG via ROS-mediated mechanism in the airway epithelium leading to persistent airway inflammation in TDI-OA patients.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsthma-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHInflammation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOccupational Diseases-
dc.subject.MESHReactive Oxygen Species-
dc.subject.MESHRespiratory Hypersensitivity-
dc.subject.MESHToluene 2,4-Diisocyanate-
dc.subject.MESHTransglutaminases-
dc.subject.MESHYoung Adult-
dc.titleTissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma.-
dc.typeArticle-
dc.identifier.pmid19562471-
dc.contributor.affiliatedAuthor박, 상면-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s10875-009-9314-8-
dc.citation.titleJournal of clinical immunology-
dc.citation.volume29-
dc.citation.number6-
dc.citation.date2009-
dc.citation.startPage786-
dc.citation.endPage794-
dc.identifier.bibliographicCitationJournal of clinical immunology, 29(6). : 786-794, 2009-
dc.identifier.eissn1573-2592-
dc.relation.journalidJ002719142-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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