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Neurally induced umbilical cord blood cells modestly repair injured spinal cords.

Authors
Cho, SR; Yang, MS; Yim, SH; Park, JH; Lee, JE; Eom, YW; Jang, IK; Kim, HE; Park, JS; Kim, HO; Lee, BH; Park, CI; Kim, YJ
Citation
Neuroreport, 19(13):1259-1263, 2008
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Umbilical cord blood (UCB) is known to have stem/progenitor cells. We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high efficiency. The multipotent progenitor cells were induced to differentiate into neural-lineage cells under the appropriate condition. In this study, we confirmed these neurally induced progenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in rats with spinal cord injury (SCI). Sprague-Dawley rats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treated with NPCs also showed somatosensory-evoked potentials were recovered, and grafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity. These findings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords.
MeSH terms
AnimalsBehavior, Animal/physiologyCell DifferentiationCells, CulturedCord Blood Stem Cell Transplantation/methods*Electrophysiology/methodsEnzyme-Linked Immunosorbent AssayEvoked Potentials, Somatosensory/physiologyGlial Fibrillary Acidic Protein/geneticsGlial Fibrillary Acidic Protein/metabolismHumansImmunohistochemistryMaleMotor Activity/physiologyMyelin Basic Proteins/geneticsMyelin Basic Proteins/metabolismRatsRats, Sprague-DawleyRecovery of Function/physiology*Reverse Transcriptase Polymerase Chain ReactionSpinal Cord Injuries/physiopathologySpinal Cord Injuries/surgery*Stem Cells/cytologyStem Cells/metabolism*
DOI
10.1097/WNR.0b013e3283089234
PMID
18695504
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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