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Pharmacogenetics of aspirin-intolerant asthma.

Authors
Kim, SH; Hur, GY; Choi, JH; Park, HS
Citation
Pharmacogenomics, 9(1):85-91, 2008
Journal Title
Pharmacogenomics
ISSN
1462-24161744-8042
Abstract
Leukotriene overproduction is the major characteristic of aspirin-intolerant asthma (AIA). Most studies examining the molecular genetic mechanisms of AIA have focused on leukotriene-related genes, including ALOX5, LTC4S, TXA2R and prostanoid-receptor genes. One study suggested that the human leukocyte antigen (HLA) allele DPB1*0301 may be a genetic marker for the AIA phenotype in European and Asian populations, and HLA-DPB1*0301 has been suggested as a useful genetic marker for predicting more favorable responders to leukotriene-receptor antagonists for long-term management of AIA. Although several reports have indicated possible associations between genetic polymorphisms and variable responses to leukotriene modifiers in nonaspirin sensitive asthmatic patients, few have suggested relationships between such genetic polymorphisms and variable responses to asthma drugs in AIA patients.
MeSH terms
AnimalsAnti-Inflammatory Agents, Non-Steroidal/adverse effects*Aspirin/adverse effects*Asthma/chemically induced*Asthma/genetics*Asthma/metabolismGenetic MarkersHumansLeukotrienes/biosynthesis
DOI
10.2217/14622416.9.1.85
PMID
18154450
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김승현허규영박해심
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