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Changes in serum histologic surrogate markers and procollagen III N-terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy

Authors
Koo, JH; Lee, MH; Kim, SS; Kim, DH; Kim, IS; Lee, KM; Yoo, BM; Lee, KJ; Kim, JH; Cho, SW; Cheong, JY
Citation
Clinical biochemistry, 45(1-2):31-36, 2012
Journal Title
Clinical biochemistry
ISSN
0009-91201873-2933
Abstract
OBJECTIVES: The aims of this study were to determine the changes in serum histologic surrogate markers and to identify the serum markers predicting treatment response in patients with chronic hepatitis B (CHB) during entecavir treatment.



DESIGN AND METHODS: Sixty CHB patients who received entecavir for 12 months were included. We assessed serum markers of liver fibrosis and/or inflammation at baseline and after 12 months of entecavir treatment.



RESULTS: The procollagen III N-terminal peptide (PIIINP) and TIMP1, MMP2, hyaluronic acid and cytokeratin 18 fragment levels were significantly decreased and the haptoglobin level was significantly increased from baseline after entecavir treatment. Multivariate analysis identified PIIINP (P=0.028) and the initial virologic response (P=0.019) as independent predictors of HBeAg loss.



CONCLUSION: During entecavir treatment, most serum markers of liver fibrosis and inflammation improved in patients with CHB. The PIIINP level at baseline and the initial virologic response are independent predictors of HBeAg loss.
MeSH terms
AdultAntiviral Agents/therapeutic useBiological Markers/metabolismFemaleFibrosis/blood/virologyGuanine/*analogs & derivatives/therapeutic useHepatitis B/*blood/*therapyHepatitis B e Antigens/immunologyHepatitis B virus/*metabolismHumansHyaluronic Acid/metabolismInflammation/blood/virologyKeratin-18/biosynthesisMaleMatrix Metalloproteinase 2/biosynthesisMiddle AgedPeptide Fragments/*chemistryProcollagen/*chemistryRetrospective StudiesTissue Inhibitor of Metalloproteinase-1/biosynthesis
DOI
10.1016/j.clinbiochem.2011.09.023
PMID
22019950
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
이, 명희김, 순선이, 기명유, 병무이, 광재김, 진홍조, 성원정, 재연
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