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Interleukin-1ß and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection

Authors
Kim, SS; Cheong, JY; Lee, D; Lee, SK; Kim, MH; Kwack, K; Yang, SJ; Lee, HY; Cho, SW
Citation
Hepato-gastroenterology, 59(113):190-197, 2012
Journal Title
Hepato-gastroenterology
ISSN
0172-6390
Abstract
BACKGROUND/AIMS: The reasons for persistent HBV infection are unknown, but they are probably related to host immune factors. IL-1ß plays significant roles in inflammation and immune defense via IL-1RAcP. We investigated whether genetic polymorphisms of IL-1ß and IL-1RAcP genes are associated with persistent HBV infection and the presence of HCC.



METHODOLOGY: We enrolled a total of 292 patients with chronic HBV infection (111 with chronic hepatitis, 95 with liver cirrhosis and 86 with HCC) and 107 healthy individuals who recovered from HBV infection. We assessed 28 SNPs in IL- 1ß and IL-1RAcP genes by using Illumina's Sentrix array matrix chip.



RESULTS: IL-1ß-2023 C allele, IL-1RAcP -8261 T allele and -8183 A allele were significantly associated with persistent HBV infection (OR=1.63, p=0.03, OR=0.64, p<0.01 and OR=0.20, p=0.01, respectively). IL- 1ß 289 C allele was marginally associated with an increased risk for the presence of HCC (OR=1.55, p=0.04). On the haplotype analysis, IL-1ß-2023C/-581C/2893C haplotype and IL-1RAcP -8261T/-8183A haplotype were associated with persistent HBV infection. There was no significant association between the haplotypes of IL-1ß/IL-1RAcP and the presence of HCC.



CONCLUSIONS: The genetic polymorphisms of IL-1ß-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.
MeSH terms
AdultAsian Continental Ancestry Group/geneticsCarcinoma, Hepatocellular/genetics/immunology/virologyChi-Square DistributionFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHepatitis B, Chronic/complications/ethnology/*genetics/immunologyHumansInterleukin-1 Receptor Accessory Protein/*geneticsInterleukin-1beta/*geneticsLinkage DisequilibriumLiver Cirrhosis/genetics/immunology/virologyLiver Neoplasms/genetics/immunology/virologyLogistic ModelsMaleMiddle AgedOdds RatioOligonucleotide Array Sequence AnalysisPhenotype*Polymorphism, Single NucleotideRepublic of Korea/epidemiologyRisk AssessmentRisk Factors
DOI
10.5754/hge10375
PMID
22251538
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
김, 순선정, 재연조, 성원
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