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Clinical characteristics of lupus myocarditis in Korea.

Authors
Chung, JW; Joe, DY; Park, HJ; Kim, HA; Park, HS; Suh, CH
Citation
Rheumatology international, 28(3):275-280, 2008
Journal Title
Rheumatology international
ISSN
0172-81721437-160X
Abstract
Clinically important myocarditis is an unusual feature in systemic lupus erythematosus (SLE). We describe the clinical characteristics, management and outcomes of five SLE patients who developed severe left ventricular dysfunction. Four patients were female with mean age of 36.4 years. Three patients had both lupus myocarditis and lupus nephritis. Four patients had raised anti-dsDNA antibody titer and low complement level and two patients had positive IgG anticardiolipin antibody. Three patients were treated by high-dose corticosteroids, one patient by intravenous pulse methylprednisolone, and one patient by intravenous immunoglobulin and pulse cyclophosphamide with high dose corticosteroids. Left ventricular function improved markedly in four patients and all of them had no recurrence of lupus myocarditis up to follow-up of 33 months. However, one patient, who showed no improvement of left ventricular function, was expired due to sudden cardiac arrest. Lupus myocarditis should be treated by immunosuppressive therapy with high-dose corticosteroids and mostly the prognosis might be good with early treatment.
MeSH terms
Adrenal Cortex Hormones/administration & dosageAdrenal Cortex Hormones/therapeutic useAdultCyclophosphamide/administration & dosageCyclophosphamide/therapeutic useDeath, Sudden, CardiacDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansImmunoglobulins, Intravenous/administration & dosageImmunoglobulins, Intravenous/therapeutic useImmunosuppressive Agents/therapeutic use*KoreaLupus Erythematosus, Systemic/drug therapy*Lupus Nephritis/drug therapy*MaleMethylprednisolone/administration & dosageMethylprednisolone/therapeutic useMiddle AgedMyocarditis/drug therapy*Time FactorsTreatment OutcomeVentricular Dysfunction, Left/drug therapy*Young Adult
DOI
10.1007/s00296-007-0414-6
PMID
17634899
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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