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Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Authors
Suk, KT; Kim, DJ; Kim, CH; Park, SH; Cheong, JY; Cho, SW; Choi, JY; Han, KH; Sung, HT; Hong, SH; Kim, DY; Yoon, JH; Kim, YS; Baik, GH; Kim, JB
Citation
Clinical biochemistry, 45(13-14):1075-1080, 2012
Journal Title
Clinical biochemistry
ISSN
0009-91201873-2933
Abstract
OBJECTIVES: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver.



METHODS: Patients with chronic viral hepatitis (n=101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled.



RESULTS: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (-3.13+0.017×MMP2-0.019×haptoglobin and -0.270+0.007×HA-0.018×haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p=0.03), MMP2 (0.72/0.63, p=0.04), HA (0.79/0.76, p=0.94), Apo-A1 (0.56/0.48, p=0.73), and predictive logit-model (0.81/0.78, p=0.68) showed higher diagnostic value in the HV sample.



CONCLUSIONS: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
MeSH terms
AdultApolipoprotein A-I/bloodArea Under CurveBiological Markers/blood/chemistryBiopsy, Fine-NeedleFemaleHaptoglobins/analysisHepacivirus/pathogenicityHepatic Veins/*chemistryHepatitis B virus/pathogenicityHepatitis B, Chronic/pathology/*virologyHepatitis C, Chronic/pathology/*virologyHumansLiver Cirrhosis/*diagnosis/virologyLogistic ModelsMaleMatrix Metalloproteinase 2/bloodMiddle AgedPeptide Fragments/bloodPredictive Value of TestsProcollagen/bloodProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexTissue Inhibitor of Metalloproteinase-1/blood
DOI
10.1016/j.clinbiochem.2012.04.031
PMID
22579966
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원
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