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RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma.

Authors
Sohn, MH; Kim, SH; Kim, KW; Jee, HM; Park, HS; Kim, KE
Citation
Lung, 186(1):37-43, 2008
Journal Title
Lung
ISSN
0341-20401432-1750
Abstract
Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease. The aim of this study was to evaluate the possible role of RANTES promoter polymorphisms in children with asthma. We genotyped 271 children with atopic asthma, 55 children with nonatopic asthma, and 253 control children for allelic determinants at two polymorphic sites in the promoter region at positions -403G>A and -28C>G by restriction fragment length polymorphism methods. There was no significant difference in genotype and allele frequencies of the RANTES -403G>A and -28C>G polymorphisms when the atopic asthma, nonatopic asthma, and control groups were compared. However, atopic asthmatic patients who were homozygous GG for the RANTES -28C>G tended to have lower PC20 methacholine than those carrying the wild genotype. In addition, a significantly lower PC20 was demonstrated for the homozygous haplotype -403A/-28G in asthmatic children. The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
MeSH terms
AdolescentAsthma/diagnosisAsthma/genetics*Asthma/physiopathologyBronchial Hyperreactivity/diagnosisBronchial Hyperreactivity/genetics*Bronchial Hyperreactivity/physiopathologyBronchial Provocation TestsBronchoconstrictor Agents/diagnostic useCase-Control StudiesChemokine CCL5/genetics*ChildFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHomozygoteHumansKoreaMaleMethacholine Chloride/diagnostic usePhenotypePolymorphism, Genetic*Promoter Regions, Genetic*Risk Factors
DOI
10.1007/s00408-007-9049-3
PMID
17990036
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현박, 해심
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