Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
Cho, HJ; Kim, SS; Ahn, SJ; Bae, CB; Kim, HG; Kim, YJ; Lee, SK; Song, GW; Kim, DJ; Hwang, SG; Yang, JM; Kim, YB; Park, YN; Cho, SW; Cheong, JY
Clinical biochemistry, 45(18):1564-1567, 2012
OBJECTIVES: The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).
DESIGN AND METHODS: Between October 2005 and June 2009, 384 subjects with CHB were enrolled.
RESULTS: Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score=1.773×ALT score+1.599×PIIINP score+0.677×HA score-1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.
CONCLUSIONS: A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB.
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