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Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B

Authors
Cho, HJ; Kim, SS; Ahn, SJ; Bae, CB; Kim, HG; Kim, YJ; Lee, SK; Song, GW; Kim, DJ; Hwang, SG; Yang, JM; Kim, YB; Park, YN; Cho, SW; Cheong, JY
Citation
Clinical biochemistry, 45(18):1564-1567, 2012
Journal Title
Clinical biochemistry
ISSN
0009-91201873-2933
Abstract
OBJECTIVES: The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).



DESIGN AND METHODS: Between October 2005 and June 2009, 384 subjects with CHB were enrolled.



RESULTS: Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score=1.773×ALT score+1.599×PIIINP score+0.677×HA score-1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.



CONCLUSIONS: A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB.
DOI
10.1016/j.clinbiochem.2012.07.107
PMID
22885475
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 순선김, 영배조, 성원정, 재연
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