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Usefulness of minimum stent cross sectional area as a predictor of angiographic restenosis after primary percutaneous coronary intervention in acute myocardial infarction (from the HORIZONS-AMI Trial IVUS substudy)

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dc.contributor.authorChoi, SY-
dc.contributor.authorMaehara, A-
dc.contributor.authorCristea, E-
dc.contributor.authorWitzenbichler, B-
dc.contributor.authorGuagliumi, G-
dc.contributor.authorBrodie, B-
dc.contributor.authorKellett, MA Jr-
dc.contributor.authorDressler, O-
dc.contributor.authorLansky, AJ-
dc.contributor.authorParise, H-
dc.contributor.authorMehran, R-
dc.contributor.authorMintz, GS-
dc.contributor.authorStone, GW-
dc.date.accessioned2013-04-22T05:12:30Z-
dc.date.available2013-04-22T05:12:30Z-
dc.date.issued2012-
dc.identifier.issn0002-9149-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7788-
dc.description.abstractHORIZONS-AMI was a prospective dual-arm randomized trial of different antithrombotic regimens and stent types in patients with ST-segment elevation myocardial infarction. A formal intravascular ultrasound (IVUS) substudy enrolled 464 patients with baseline and 13-month follow-up at 36 centers. Of them, 318 patients with 355 lesions were evaluated for this study. Angiographic restenosis occurred in 45 of 355 lesions (12.7%). Bare-metal stent use (45.5% vs 21.2%, p <0.001) and diabetes mellitus (29.5% vs 10.9%, p <0.001) were more prevalent in patients with versus without restenosis. Postprocedure IVUS minimum lumen area (5.6 mm(2), 5.0 to 6.1, vs 6.7 mm(2), 6.5 to 6.9, p <0.001), minimum stent area (5.7 mm(2), 5.1 to 6.3, vs 6.9 mm(2), 6.6 to 7.1, p <0.001), and reference average lumen area (7.7 mm(2), 6.8 to 8.6, vs 9.7 mm(2), 9.3 to 10.1, p <0.001) were smaller in restenotic versus nonrestenotic lesions. By multivariable analysis, minimum stent area was an independent predictor of angiographic restenosis (odds ratio 0.75, 95% confidence interval 0.61 to 0.93, p = 0.009) in addition to diabetes, bare-metal stent use, and longer stent length. Attenuated plaque behind the stent struts had a trend to predict less binary restenosis (p = 0.07). In conclusion, a smaller IVUS minimum stent area was an independent predictor of angiographic restenosis after primary percutaneous intervention in patients with ST-segment elevation myocardial infarction, similar to patients with stable coronary artery disease.-
dc.language.isoen-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Restenosis-
dc.subject.MESHCoronary Vessels-
dc.subject.MESHDiabetes Mellitus-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHMyocardial Infarction-
dc.subject.MESHProspective Studies-
dc.subject.MESHProsthesis Design-
dc.subject.MESHStents-
dc.subject.MESHUltrasonography, Interventional-
dc.titleUsefulness of minimum stent cross sectional area as a predictor of angiographic restenosis after primary percutaneous coronary intervention in acute myocardial infarction (from the HORIZONS-AMI Trial IVUS substudy)-
dc.typeArticle-
dc.identifier.pmid22118823-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0002-9149(11)03032-3-
dc.contributor.affiliatedAuthor최, 소연-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.amjcard.2011.10.005-
dc.citation.titleThe American journal of cardiology-
dc.citation.volume109-
dc.citation.number4-
dc.citation.date2012-
dc.citation.startPage455-
dc.citation.endPage460-
dc.identifier.bibliographicCitationThe American journal of cardiology, 109(4). : 455-460, 2012-
dc.identifier.eissn1879-1913-
dc.relation.journalidJ000029149-
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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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