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Identification of Dioscorea batatas (sanyak) allergen as an inhalant and oral allergen.

Authors
Hur, GY; Park, HJ; Kim, HA; Ye, YM; Park, HS
Citation
Journal of Korean medical science, 23(1):72-76, 2008
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Dioscorea batatas is widely used in Asia as a herbal medicine or food product with potential health benefits. There have been several reports of occupational asthma caused by inhalation of D. batatas dust. However, there has been no report of systemic allergic reactions after oral administration of D. batatas. Two patients with D. batatas allergy were enrolled. One had experienced severe urticaria and angioedema after indigestion, and the other had been exposed to D. batatas dust and was diagnosed as having occupational asthma. Both patients had high serum-specific IgE and IgG4 antibodies to D. batatas. And IgE immunoblot demonstrated that both sera bound to a 27-kDa protein with an IgE-binding motif, which was revealed by 2-D-electrophoresis to have the sequence Asn-Val-Glu-Asp-Glu-Phe-Ser-X-Ile- Glu-Gly-Asn-Pro-X-X-Pro-Glu-Asn-X-Gly (pI 6.40, 6.04). In conclusion, discorin from D. batatas (DB3S) was identified as the major allergen of D. batatas in patients sensitized via an oral or inhalant route.
MeSH terms
Administration, InhalationAdministration, OralAdultAllergens/immunology*Amino Acid SequenceDioscorea/immunology*Electrophoresis, Gel, Two-DimensionalEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoblottingImmunoglobulin E/bloodImmunoglobulin G/bloodMolecular Sequence Data
DOI
10.3346/jkms.2008.23.1.72
PMID
18303202
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
허, 규영김, 현아예, 영민박, 해심
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