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Cytokines and their receptors as biomarkers of systemic lupus erythematosus.

Authors
Suh, CH; Kim, HA
Citation
Expert review of molecular diagnostics, 8(2):189-198, 2008
Journal Title
Expert review of molecular diagnostics
ISSN
1473-71591744-8352
Abstract
Systemic lupus erythematosus is the most clinically diverse autoimmune disease. Owing to its heterogeneous presentation, clinical management of systemic lupus erythematosus remains as one of the greatest challenges. Therefore, there is a great need to assess disease activity accurately. Biomarkers can be objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes or pharmacologic responses to a therapeutic intervention, and may also predict the risk of the disease, confirm diagnosis, monitor disease activity and provide prognostic information. Cytokines play an important and diverse role in the immune dysregulation in systemic lupus erythematosus. Measuring serum levels of soluble IL-2 receptor, IL-6, IL-10, soluble TNF receptor and IFN-alpha/IFN-induced genes may be promising biomarkers of disease activity in systemic lupus erythematosus.
MeSH terms
AnimalsBiological Markers/bloodCytokines/blood*Cytokines/immunologyHumansLupus Erythematosus, Systemic/blood*Lupus Erythematosus, Systemic/diagnosisLupus Erythematosus, Systemic/immunologyLupus Erythematosus, Systemic/therapyMonitoring, Physiologic/methodsPrognosisReceptors, Cytokine/blood*Receptors, Cytokine/immunology
DOI
10.1586/14737159.8.2.189
PMID
18366305
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
서창희김현아
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