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Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type: clinical manifestation and outcome of a rare disease - consortium for improving survival of lymphoma study

Oh, SY; Kim, WS; Kim, JS; Kim, SJ; Lee, S; Lee, DH; Kang, HJ; Song, MK; Kim, HJ; Kwon, JH; Kwak, JY; Park, BB; Do, YR; Jeong, SH; Suh, C
Acta haematologica, 127(2):100-104, 2012
Journal Title
Acta haematologica
PURPOSE: Primary thyroid marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type (pTY-MZL) is an extremely uncommon form of lymphoma. Due to its rarity, the natural history and optimal treatment modality for this disease have yet to be clearly established.

METHODS: A total of 27 patients with histologically confirmed pTY-MZL were retrospectively analyzed.

RESULTS: The median age of our subjects was 53 years (range 25-82). This study involved 17 females (63.0%) and 10 males (37.0%). Twenty-four out of 27 patients (88.9%) initially presented with localized disease, defined by Ann Arbor stage I/II. Bone marrow involvement was detected in 8.3% of the patients (2 patients), and 91.7% of the patients (25 of 27) were categorized into the low or low-intermediate risk group, according to the International Prognostic Index criteria. Accompanying Hashimoto's thyroiditis was detected in 72% of the patients, whereas thyroglobulin antibody levels were elevated in 70% of the patients. Twenty-six patients were treated with surgery, radiotherapy or chemotherapy, and 25 patients achieved complete remission. During the follow-up period, only 2 patients evidenced progression, and no deaths occurred over the course of the study.

CONCLUSION: pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients' responses were sustained for a prolonged period.
MeSH terms
AdultAgedAged, 80 and overCombined Modality TherapyFemaleHumansLymphoma, B-Cell, Marginal Zone/*pathology/therapyMaleMiddle AgedPrognosisRetrospective StudiesThyroid Neoplasms/*pathology/therapyTreatment Outcome
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Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
정, 성현
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