Cited 0 times in Scipus Cited Count

Clinical features and outcomes of Hodgkin's lymphoma in Korea: Consortium for Improving Survival of Lymphoma (CISL)

DC Field Value Language
dc.contributor.authorWon, YW-
dc.contributor.authorKwon, JH-
dc.contributor.authorLee, SI-
dc.contributor.authorOh, SY-
dc.contributor.authorKim, WS-
dc.contributor.authorKim, SJ-
dc.contributor.authorWon, JH-
dc.contributor.authorKim, KH-
dc.contributor.authorPark, SK-
dc.contributor.authorKim, JS-
dc.contributor.authorSuh, C-
dc.contributor.authorYoon, DH-
dc.contributor.authorPark, JS-
dc.contributor.authorKim, MK-
dc.contributor.authorKim, H-
dc.contributor.authorKang, HJ-
dc.contributor.authorMun, YC-
dc.contributor.authorKwak, JY-
dc.contributor.authorKim, HJ-
dc.contributor.authorEom, HS-
dc.date.accessioned2013-04-23-
dc.date.available2013-04-23-
dc.date.issued2012-
dc.identifier.issn0939-5555-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7834-
dc.description.abstractEthnic and regional differences in the epidemiology and pathological aspects of Hodgkin's lymphoma (HL) between Western and Asian patients may be associated with differences in clinical features and prognosis. We retrospectively analyzed the clinical and histopathological characteristics, therapeutic outcomes, and prognostic factors of 539 HL patients treated at 16 centers in Korea. We found that the incidence of histological subtypes of HL in Korea was similar to that in Western and other Asian countries. However, the incidence peaked between 16 and 30 years of age, unlike the bimodal age distribution seen in Western countries. In patients with stage I-IIA non-bulky disease, the complete response (CR) rate was similar between combined modality therapy and chemotherapy alone (93% vs. 84%, P = 0.44), and there was no difference in relapse-free survival (RFS) and overall survival (OS). Patients with stage I-II disease plus unfavorable factors and those with advanced-stage disease treated with combination chemotherapy regimens had an overall CR rate of 77%, with no difference between doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and non-ABVD regimens (77.2% vs. 76.8%, P = 0.95). Among those patients who achieved final CR, there was no significant difference in RFS or OS between those who achieved interim CR and PR. Only the presence of B symptoms was independently predictive of a shorter RFS. Age > 45 years, Eastern Cooperative Oncology Group 2-4, and B symptoms were independent risk factors for death. Although the incidence of HL was lower in Korea than in Western countries, the distribution of morphological subtypes, treatment outcomes, and patient prognosis were similar.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHodgkin Disease-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleClinical features and outcomes of Hodgkin's lymphoma in Korea: Consortium for Improving Survival of Lymphoma (CISL)-
dc.typeArticle-
dc.identifier.pmid21789622-
dc.contributor.affiliatedAuthor박, 준성-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00277-011-1297-x-
dc.citation.titleAnnals of hematology-
dc.citation.volume91-
dc.citation.number2-
dc.citation.date2012-
dc.citation.startPage223-
dc.citation.endPage233-
dc.identifier.bibliographicCitationAnnals of hematology, 91(2). : 223-233, 2012-
dc.identifier.eissn1432-0584-
dc.relation.journalidJ009395555-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse