58 396

Cited 32 times in

Prevalence of work-related symptoms and serum-specific antibodies to wheat flour in exposed workers in the bakery industry.

Hur, GY; Koh, DH; Kim, HA; Park, HJ; Ye, YM; Kim, KS; Park, HS
Respiratory medicine, 102(4):548-555, 2008
Journal Title
Respiratory medicine
BACKGROUND: Although baker's asthma (BA) is a common occupational asthma, there have been few reports on this disease in Korean subjects.

OBJECTIVES: We evaluated the prevalence of serum-specific IgE, IgG1, and IgG4 antibodies in relation to work-related respiratory symptoms in a single industrial bakery.

METHODS: Three hundred and ninety-two bakery workers were administered and taken a questionnaire regarding respiratory symptoms. For symptomatic workers, the methacholine bronchial challenge test and specific bronchoprovocation tests with wheat extracts were carried out. Skin prick tests were performed and serum-specific IgE, IgG1, and IgG4 antibodies to wheat flour were detected. The IgE- and IgG4-binding components were identified by immunoblotting.

RESULTS: Sixty-seven workers (17.1%) complained of work-related upper and lower respiratory symptoms. The prevalence of BA based on positive bronchoprovocation test results was 1.5%. The sensitization rate to wheat flour was 5.9% by skin prick test and 6.5% by ELISA, and was closely associated with the presence of atopy and work-related lower respiratory symptoms (P<0.001 for both). IgE immunoblotting revealed six major IgE-binding components (27, 31, 36, 43, 54, and 72 kDa). The presence of wheat-specific IgG1 and IgG4 antibodies was found to be significantly associated with exposure intensity (P<0.05 for both).

CONCLUSIONS: The overall prevalence of wheat sensitization in a Korean bakery was 5.9%. We confirmed that an IgE-mediated response is the major pathogenic mechanism for the induction of work-related symptoms in wheat-exposed workers. Wheat-specific IgG antibodies may represent current or previous exposure to wheat dust.
MeSH terms
AdultAsthma/etiology*Asthma/immunologyBreadBronchial Provocation TestsBronchoconstrictor Agents/diagnostic useElectrophoresis, Polyacrylamide GelFemaleFlour*HumansImmunoblottingImmunoglobulin E/bloodImmunoglobulin G/bloodIndustry*KoreaMaleMethacholine Chloride/diagnostic useOccupational Diseases/etiology*Occupational Diseases/immunologyOccupational ExposurePrevalenceRespiratory HypersensitivitySecale cerealeSkin TestsTriticum*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 현아박, 한정예, 영민박, 해심
Full Text Link
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.