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Neutrophil activation in patients with ASA-induced urticaria.

Authors
Choi, SJ; Ye, YM; Hur, GY; Shin, SY; Han, JH; Park, HS
Citation
Journal of clinical immunology, 28(3):244-249, 2008
Journal Title
Journal of clinical immunology
ISSN
0271-91421573-2592
Abstract
The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.
MeSH terms
Acute DiseaseAdministration, OralAdultAngioedema/chemically inducedAngioedema/enzymologyAngioedema/immunologyAngioedema/pathologyAspirin/administration & dosageAspirin/adverse effects*Chronic DiseaseCytokines/biosynthesisCytokines/bloodDrug Hypersensitivity/enzymologyDrug Hypersensitivity/immunologyDrug Hypersensitivity/pathologyFemaleHumansHypersensitivity, Immediate/enzymologyHypersensitivity, Immediate/immunologyHypersensitivity, Immediate/pathologyMaleNeutrophil Activation/drug effects*Neutrophil Activation/immunology*Neutrophils/drug effectsNeutrophils/enzymologyNeutrophils/immunology*Peroxidase/bloodUrticaria/chemically induced*Urticaria/enzymologyUrticaria/immunologyUrticaria/pathology
DOI
10.1007/s10875-007-9165-0
PMID
18204966
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
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