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Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis

DC Field Value Language
dc.contributor.authorLee, SK-
dc.contributor.authorKim, SD-
dc.contributor.authorKook, M-
dc.contributor.authorLee, HY-
dc.contributor.authorPark, JS-
dc.contributor.authorPark, YH-
dc.contributor.authorKang, JS-
dc.contributor.authorJung, WJ-
dc.contributor.authorChoi, YW-
dc.contributor.authorBae, YS-
dc.date.accessioned2013-04-23T01:56:30Z-
dc.date.available2013-04-23T01:56:30Z-
dc.date.issued2012-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7850-
dc.description.abstractα-Iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, strongly enhances survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. Mechanistically, α-iso-cubebenol markedly reduces viable bacteria in the peritoneal fluid and peripheral blood, by increasing production of superoxide anion. α-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1β (IL-1β) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. Taken together, the results indicate that α-iso-cubebenol can reverse the progression of septic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBacteria/drug effects-
dc.subject.MESHBiological Agents/*therapeutic use-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHSchisandra/*chemistry-
dc.subject.MESHSepsis/*drug therapy-
dc.subject.MESHSesquiterpenes/administration & dosage/*therapeutic use-
dc.titleTherapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis-
dc.typeArticle-
dc.identifier.pmid23022181-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0006-291X(12)01841-4-
dc.contributor.affiliatedAuthor박, 준성-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.bbrc.2012.09.094-
dc.citation.titleBiochemical and biophysical research communications-
dc.citation.volume427-
dc.citation.number3-
dc.citation.date2012-
dc.citation.startPage547-
dc.citation.endPage552-
dc.identifier.bibliographicCitationBiochemical and biophysical research communications, 427(3):547-552, 2012-
dc.identifier.eissn1090-2104-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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