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Waldeyer's ring marginal zone B cell lymphoma: are the clinical and prognostic features nodal or extranodal? A study by the Consortium for Improving Survival of Lymphoma (CISL)

Authors
Oh, SY; Kim, WS; Kim, JS; Kim, SJ; Lee, S; Lee, DH; Lee, SI; Kang, HJ; Choi, CW; Park, J; Song, MK; Kim, HJ; Kwon, JH; Kwak, JY; Bae, SH; Park, BB; Do, YR; Lee, HS; Jeong, SH; Suh, C
Citation
International journal of hematology, 96(5):631-637, 2012
Journal Title
International journal of hematology
ISSN
0925-57101865-3774
Abstract
There has been controversy surrounding Waldeyer's ring (WR), especially focused on the question of whether it should be regarded as a nodal or an extranodal site. We conducted retrospective analyses of marginal zone B cell lymphomas involving WR (WR-MZLs) to observe their clinical features and prognosis, with specific regard to the nodal-or-extranodal question. A total of 52 patients with histological diagnosis of WR-MZL were retrospectively analyzed. The most common involvement site was the tonsil (40.4 %). Ann Arbor stage III/VI disease was present in 48.1 % (25 of 52). The response rate of the 27 stage I/II patients was 88.9 %, with 21 complete remissions and three partial remissions. The median time to progression (TTP) was 3.7 years (95 % CI 2.5-4.9 years). The estimated 5-year TTP and overall survival rates were 39.4 and 90.5 %, respectively. In a comparison with the historical data regarding extra-WR MALT lymphoma and nodal MZL (N-MZL), MALT lymphoma showed better TTP results than did WR-MZL and N-MZL (P < 0.001).
DOI
10.1007/s12185-012-1200-0
PMID
23065471
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
정, 성현
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