70 229

Cited 22 times in

Fluoroquinolone resistance in uncomplicated acute pyelonephritis: epidemiology and clinical impact

Shin, J; Kim, J; Wie, SH; Cho, YK; Lim, SK; Shin, SY; Yeom, JS; Lee, JS; Kweon, KT; Lee, H; Cheong, HJ; Park, SH; Park, DW; Ryu, SY; Chung, MH; Yoo, S; Pai, H
Microbial drug resistance (Larchmont, N.Y.), 18(2):169-175, 2012
Journal Title
Microbial drug resistance (Larchmont, N.Y.)
The objectives of this study were to investigate antibiotic resistance in urinary pathogens from Korean patients with uncomplicated acute pyelonephritis (UAPN), and to determine the effect of fluoroquinolone (FQ) resistance on clinical outcome in those patients with UAPN initially treated with FQ. Clinical and microbiologic data for all the APN patients attending 14 hospitals in South Korea in 2008 were collected retrospectively. Urinary pathogens were identified in 719 cases, and Escherichia coli was the most common pathogen (661/719, 91.9%). Antibiotic susceptibilities to several E. coli antibiotics were as follows: ciprofloxacin, 84.1%; trimethoprim-sulfamethoxazola (TMP-SMX), 67.2%; and extended-spectrum beta-lactamase-negative, 92.4%. FQ was the most frequent antibiotic prescribed for UAPN (45.3% intravenously and 53.9% by mouth). We compared clinical outcomes and hospital days in patients with FQ-resistant (32) and FQ-sensitive E. coli (173) who received FQ as initial empirical therapy. Clinical cure was higher in the FQ-sensitive group (78% vs. 91%, p=0.027), and hospital days were longer in the FQ-resistant group (9.6±5.5 days vs. 7±3.5 days, p=0.001). In conclusion, FQ-sensitivity of E. coli from UAPN was 84.1%. FQ treatment of UAPN caused by FQ-resistant E. coli has a lower cure rate and involves longer hospital stay than FQ treatment of cases caused by FQ-sensitive E. coli.
MeSH terms
Acute DiseaseAdultAgedAnti-Bacterial Agents/*pharmacology/therapeutic useCiprofloxacin/pharmacology/therapeutic use*Drug Resistance, BacterialEscherichia coli/*drug effects/isolation & purificationEscherichia coli Infections/drug therapy/epidemiology/microbiologyFemaleFluoroquinolones/*pharmacology/therapeutic useHumansLength of StayMaleMicrobial Sensitivity TestsMiddle AgedPyelonephritis/*drug therapy/*epidemiology/microbiologyRepublic of Korea/epidemiologyTreatment OutcomeUrine/microbiology
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
AJOU Authors
임, 승관
Files in This Item:
fulltext not available.txtDownload
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.