Cited 0 times in Scipus Cited Count

Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis

DC Field Value Language
dc.contributor.authorPark, HJ-
dc.contributor.authorKim, JH-
dc.contributor.authorKim, JE-
dc.contributor.authorJin, HJ-
dc.contributor.authorChoi, GS-
dc.contributor.authorYe, YM-
dc.contributor.authorPark, HS-
dc.date.accessioned2013-04-23T05:45:55Z-
dc.date.available2013-04-23T05:45:55Z-
dc.date.issued2012-
dc.identifier.issn1018-2438-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/7871-
dc.description.abstractBACKGROUND: Wheat is an important food allergen associated with severe allergic reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and wheat-induced anaphylaxis (WIA). To diagnose WDEIA, an exercise challenge test following wheat ingestion is performed, which is time-consuming and unsafe. The compound ω-5 gliadin has been identified as a major allergen for WDEIA and WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of ω-5 gliadin to wheat in adult patients with WDEIA or WIA.



METHODS: In total, 27 patients were enrolled and classified into 2 groups according to the severity of their allergic reactions to wheat. Serum IgE, specific to wheat and ω-5 gliadin, was measured using the ImmunoCAP system. To evaluate the diagnostic value, receiver operator characteristic curves were produced.



RESULTS: Group 1 included 17 patients with a history of anaphylaxis and group 2 included 10 patients having urticaria or atopic dermatitis. Serum IgE specific to wheat was increased in 47% of group 1 and 100% of group 2. However, all patients in group 1 had high serum IgE specific to ω-5 gliadin, whereas only 20% of group 2 showed increased levels. To identify a better diagnostic value, the log-transformed IgE ratio of ω-5 gliadin to wheat was calculated, with the cutoff value at 0.3. Based on these criteria, we found 100% sensitivity and specificity.



CONCLUSIONS: This study confirms that the serum IgE ratio of ω-5 gliadin to wheat may be a useful marker for the diagnosis of WDEIA and WIA.
-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAllergens-
dc.subject.MESHAnaphylaxis-
dc.subject.MESHAntibody Specificity-
dc.subject.MESHAntigens, Plant-
dc.subject.MESHFemale-
dc.subject.MESHGliadin-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTriticum-
dc.subject.MESHWheat Hypersensitivity-
dc.subject.MESHYoung Adult-
dc.titleDiagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis-
dc.typeArticle-
dc.identifier.pmid21985845-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000327549-
dc.contributor.affiliatedAuthor진, 현정-
dc.contributor.affiliatedAuthor예, 영민-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000327549-
dc.citation.titleInternational archives of allergy and immunology-
dc.citation.volume157-
dc.citation.number2-
dc.citation.date2012-
dc.citation.startPage147-
dc.citation.endPage150-
dc.identifier.bibliographicCitationInternational archives of allergy and immunology, 157(2). : 147-150, 2012-
dc.identifier.eissn1423-0097-
dc.relation.journalidJ010182438-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse