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Association of four-locus gene interaction with aspirin-intolerant asthma in Korean asthmatics.
DC Field | Value | Language |
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dc.contributor.author | Kim, SH | - |
dc.contributor.author | Jeong, HH | - |
dc.contributor.author | Cho, BY | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Lee, J | - |
dc.contributor.author | Wee, K | - |
dc.contributor.author | Park, HS | - |
dc.date.accessioned | 2010-12-24T01:13:28Z | - |
dc.date.available | 2010-12-24T01:13:28Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0271-9142 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/788 | - |
dc.description.abstract | INTRODUCTION: Aspirin-intolerant asthma (AIA), a major clinical presentation of aspirin hypersensitivity, affects 10% of adult asthmatics. The genetic risk factors involved in the susceptibility to AIA have recently been investigated, but multilocus single-nucleotide polymorphisms (SNPs) associated with this susceptibility has not been evaluated.
METHODS: We examined 246 asthmatic patients: 94 having aspirin intolerance and 152 having aspirin tolerance. We selected 23 SNPs of 13 candidate genes and genotyped each SNP using a primer extension method. Multilocus genetic interactions were examined using multifactor dimensionality reduction (MDR) to test all multilocus SNP combinations to identify a useful SNP set for predicting the AIA phenotype. RESULTS: We identified the best model using the MDR method, which consisted of a four-locus gene-gene interaction with 65.16% balanced accuracy and a cross-validation consistency of 70% in predicting AIA disease risk among asthmatic patients. This model included four SNPs such as B2ADR 46A>G, CCR3-520T>G, CysLTR1-634C>T, and FCER1B-109T>C. DISCUSSION: These results suggest that a multilocus SNP acts in combination to influence the susceptibility to aspirin intolerance in asthmatics and could be a useful genetic marker for the diagnosis of AIA. | - |
dc.language.iso | en | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aspirin | - |
dc.subject.MESH | Asthma | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Pneumonia | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Receptors, Leukotriene | - |
dc.title | Association of four-locus gene interaction with aspirin-intolerant asthma in Korean asthmatics. | - |
dc.type | Article | - |
dc.identifier.pmid | 18379861 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s10875-008-9190-7 | - |
dc.citation.title | Journal of clinical immunology | - |
dc.citation.volume | 28 | - |
dc.citation.number | 4 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 336 | - |
dc.citation.endPage | 342 | - |
dc.identifier.bibliographicCitation | Journal of clinical immunology, 28(4). : 336-342, 2008 | - |
dc.identifier.eissn | 1573-2592 | - |
dc.relation.journalid | J002719142 | - |
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