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The antichromatin antibodies can be useful as a diagnostic tool and disease activity marker of systemic lupus erythematosus in Koreans.

Authors
Kim, HA; Jeon, JY; Choi, GS; Sung, JM; Kim, MJ; Yun, JM; Suh, CH
Citation
Clinical immunology (Orlando, Fla.), 128(2):277-283, 2008
Journal Title
Clinical immunology (Orlando, Fla.)
ISSN
1521-66161521-7035
Abstract
We have investigated the clinical utility of antichromatin antibodies for the diagnosis of SLE and as a marker of disease activity in Korean SLE patients. Blood samples were collected from SLE patients, lupus syndrome patients having only two or three of ACR classification criteria for SLE and normal controls. The level of antichromatin antibody was measured by enzyme linked immunosorbent assay and expressed as arbitrary unit. The antichromatin antibody levels of the SLE and lupus syndrome patients were higher than NC. The antichromatin antibody levels were significant higher in SLE patients with arthritis. A significant correlation was found between the level of antichromatin antibodies and each of anti-dsDNA antibody, leukopenia, complement and SLEDAI. The change of antichromatin antibody levels showed a positive correlation with the change of SLEDAI in serial samples. These data suggest that the antichromatin antibodies appear to be a useful laboratory test that can help in the diagnosis and assessment of SLE.
MeSH terms
Antibodies/blood*Autoantibodies/blood*Biological Markers/bloodChromatin/immunology*Enzyme-Linked Immunosorbent AssayHumansKoreaLupus Erythematosus, Systemic/diagnosis*Sensitivity and Specificity
DOI
10.1016/j.clim.2008.03.516
PMID
18504161
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
AJOU Authors
김, 현아최, 길순서, 창희
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